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DUSP2 dual specificity phosphatase 2 [ Homo sapiens (human) ]

Gene ID: 1844, updated on 1-Jun-2020

Summary

Official Symbol
DUSP2provided by HGNC
Official Full Name
dual specificity phosphatase 2provided by HGNC
Primary source
HGNC:HGNC:3068
See related
Ensembl:ENSG00000158050 MIM:603068
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAC1; PAC-1
Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 49.4), lymph node (RPKM 22.5) and 9 other tissues See more
Orthologs

Genomic context

See DUSP2 in Genome Data Viewer
Location:
2q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96143166..96145468, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (96808908..96811206, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene adrenoceptor alpha 2B Neighboring gene astacin like metalloendopeptidase Neighboring gene Sharpr-MPRA regulatory region 4518 Neighboring gene StAR related lipid transfer domain containing 7 Neighboring gene STARD7 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine/threonine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
endoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inactivation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 2
Names
dual specificity protein phosphatase PAC-1
serine/threonine specific protein phosphatase
NP_004409.1
XP_016859035.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004418.4NP_004409.1  dual specificity protein phosphatase 2

    See identical proteins and their annotated locations for NP_004409.1

    Status: REVIEWED

    Source sequence(s)
    BC007771, DB475178
    Consensus CDS
    CCDS2016.1
    UniProtKB/Swiss-Prot
    Q05923
    Related
    ENSP00000288943.4, ENST00000288943.5
    Conserved Domains (2) summary
    cd00127
    Location:172308
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:8143
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    96143166..96145468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003546.1XP_016859035.1  dual specificity protein phosphatase 2 isoform X1

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