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P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 [ Mus musculus (house mouse) ]

Gene ID: 18438, updated on 8-Jan-2019

Summary

Official Symbol
P2rx4provided by MGI
Official Full Name
purinergic receptor P2X, ligand-gated ion channel 4provided by MGI
Primary source
MGI:MGI:1338859
See related
Ensembl:ENSMUSG00000029470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2X4; AI504491; AW555605; D5Ertd444e
Expression
Ubiquitous expression in colon adult (RPKM 57.8), lung adult (RPKM 28.0) and 23 other tissues See more
Orthologs

Genomic context

See P2rx4 in Genome Data Viewer
Location:
5 F; 5 62.53 cM
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (122707509..122729739)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (123157566..123179053)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 7 Neighboring gene microRNA 8115 Neighboring gene 60S ribosomal protein L32-like Neighboring gene calcium/calmodulin-dependent protein kinase kinase 2, beta Neighboring gene anaphase-promoting complex subunit 5 Neighboring gene predicted gene, 33044

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATP-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding ISO
Inferred from Sequence Orthology
more info
 
copper ion binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
extracellularly ATP-gated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellularly ATP-gated cation channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellularly ATP-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
extracellularly ATP-gated cation channel activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ligand-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
purinergic nucleotide receptor activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
behavioral response to pain ISO
Inferred from Sequence Orthology
more info
 
calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cation transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to ATP ISO
Inferred from Sequence Orthology
more info
 
cellular response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of microglial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
purinergic nucleotide receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
relaxation of cardiac muscle ISO
Inferred from Sequence Orthology
more info
 
response to ATP ISO
Inferred from Sequence Orthology
more info
 
response to axon injury ISO
Inferred from Sequence Orthology
more info
 
response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
response to ischemia ISO
Inferred from Sequence Orthology
more info
 
sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
sensory perception of touch ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cell body ISO
Inferred from Sequence Orthology
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
P2X purinoceptor 4
Names
ionotropic purinergic receptor
purinergic receptor P2x4 subunit variant e

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310718.1NP_001297647.1  P2X purinoceptor 4 isoform 2

    See identical proteins and their annotated locations for NP_001297647.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC115728, AK162820, BM244734, BY150918, JX417451
    Consensus CDS
    CCDS80392.1
    UniProtKB/TrEMBL
    D3Z5U5
    Related
    ENSMUSP00000117193.2, ENSMUST00000142664.2
    Conserved Domains (1) summary
    pfam00864
    Location:13339
    P2X_receptor; ATP P2X receptor
  2. NM_001310720.1NP_001297649.1  P2X purinoceptor 4 isoform 3

    See identical proteins and their annotated locations for NP_001297649.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC115728, AF089752, AK162820, BM244734, BY150918
    Consensus CDS
    CCDS80393.1
    UniProtKB/TrEMBL
    Q9Z256
    Related
    ENSMUSP00000080269.6, ENSMUST00000081554.12
    Conserved Domains (1) summary
    pfam00864
    Location:13334
    P2X_receptor; ATP P2X receptor
  3. NM_011026.3NP_035156.2  P2X purinoceptor 4 isoform 1

    See identical proteins and their annotated locations for NP_035156.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC115728, AF089751, AK162820, BM244734, BY150918
    Consensus CDS
    CCDS19654.2
    UniProtKB/TrEMBL
    Q9Z257
    Related
    ENSMUSP00000031429.7, ENSMUST00000031429.13
    Conserved Domains (1) summary
    pfam00864
    Location:13361
    P2X_receptor; ATP P2X receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    122707509..122729739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530196.3XP_006530259.1  P2X purinoceptor 4 isoform X1

    UniProtKB/TrEMBL
    D3YYR5
    Related
    ENSMUSP00000118163.2, ENSMUST00000139631.7
    Conserved Domains (1) summary
    pfam00864
    Location:13312
    P2X_receptor; ATP P2X receptor
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