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P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 [ Mus musculus (house mouse) ]

Gene ID: 18436, updated on 27-Nov-2024

Summary

Official Symbol
P2rx1provided by MGI
Official Full Name
purinergic receptor P2X, ligand-gated ion channel, 1provided by MGI
Primary source
MGI:MGI:1098235
See related
Ensembl:ENSMUSG00000020787 AllianceGenome:MGI:1098235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P2x; RP-2; Pdcd3
Summary
Enables monoatomic cation channel activity and purinergic nucleotide receptor activity. Acts upstream of or within several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of monoatomic ion transport; and serotonin secretion by platelet. Located in external side of plasma membrane and postsynaptic membrane. Is expressed in several structures, including bladder; foregut-midgut junction; heart; liver lobe; and midgut. Orthologous to human P2RX1 (purinergic receptor P2X 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 220.3) and thymus adult (RPKM 21.4) See more
Orthologs
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Genomic context

See P2rx1 in Genome Data Viewer
Location:
11 B4; 11 45.09 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72889882..72906026)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72999056..73015200)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34793 Neighboring gene STARR-positive B cell enhancer ABC_E7013 Neighboring gene ATPase, Ca++ transporting, ubiquitous Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72820103-72820212 Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72828695-72828896 Neighboring gene STARR-positive B cell enhancer ABC_E10684 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1, alpha Neighboring gene STARR-positive B cell enhancer ABC_E5246 Neighboring gene nuclear cap binding subunit 3 Neighboring gene STARR-positive B cell enhancer mm9_chr11:72885264-72885564

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellularly ATP-gated monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables extracellularly ATP-gated monoatomic cation channel activity IEA
Inferred from Electronic Annotation
more info
 
enables extracellularly ATP-gated monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ligand-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic cation channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables organic cyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables purinergic nucleotide receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables purinergic nucleotide receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables suramin binding IEA
Inferred from Electronic Annotation
more info
 
enables suramin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within insemination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of monoatomic ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of monoatomic ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of monoatomic ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of monoatomic ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of vascular associated smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to ATP IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within serotonin secretion by platelet IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
P2X purinoceptor 1
Names
ATP receptor
P2X1 receptor
programmed cell death 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008771.3NP_032797.3  P2X purinoceptor 1

    See identical proteins and their annotated locations for NP_032797.3

    Status: VALIDATED

    Source sequence(s)
    AK007650, AK035304
    Consensus CDS
    CCDS24992.1
    UniProtKB/Swiss-Prot
    P51576, Q5SRU4
    UniProtKB/TrEMBL
    Q91WI3
    Related
    ENSMUSP00000021141.8, ENSMUST00000021141.14
    Conserved Domains (1) summary
    TIGR00863
    Location:1368
    P2X; cation transporter protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72889882..72906026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532451.2XP_006532514.1  P2X purinoceptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006532514.1

    UniProtKB/TrEMBL
    Q91WI3
    Conserved Domains (1) summary
    TIGR00863
    Location:1368
    P2X; cation transporter protein