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Mybbp1a MYB binding protein (P160) 1a [ Mus musculus (house mouse) ]

Gene ID: 18432, updated on 3-Jun-2024

Summary

Official Symbol
Mybbp1aprovided by MGI
Official Full Name
MYB binding protein (P160) 1aprovided by MGI
Primary source
MGI:MGI:106181
See related
Ensembl:ENSMUSG00000040463 AllianceGenome:MGI:106181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P160; p67MBP; p160MBP
Summary
Enables E-box binding activity and transcription corepressor activity. Involved in circadian regulation of gene expression and negative regulation of transcription, DNA-templated. Acts upstream of or within respiratory electron transport chain. Located in cytoplasm and nucleolus. Part of NLS-dependent protein nuclear import complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and limb. Orthologous to human MYBBP1A (MYB binding protein 1a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 38.4), ovary adult (RPKM 36.1) and 28 other tissues See more
Orthologs
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Genomic context

See Mybbp1a in Genome Data Viewer
Location:
11 B4; 11 44.29 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72332153..72342596)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72441327..72451770)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene smoothelin-like 2 Neighboring gene STARR-seq mESC enhancer starr_29906 Neighboring gene STARR-positive B cell enhancer ABC_E10683 Neighboring gene STARR-positive B cell enhancer ABC_E8422 Neighboring gene gamma-glutamyltransferase 6 Neighboring gene SPNS lysolipid transporter 2, sphingosine-1-phosphate Neighboring gene Spns2 opposite strand Neighboring gene SPNS lysolipid transporter 3, sphingosine-1-phosphate (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables E-box binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase I NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_negative_effect regulation of G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within respiratory electron transport chain IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of B-WICH complex ISO
Inferred from Sequence Orthology
more info
 
part_of NLS-dependent protein nuclear import complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myb-binding protein 1A
Names
myb-binding protein of 160 kDa
nuclear protein P160

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016776.3NP_058056.2  myb-binding protein 1A

    See identical proteins and their annotated locations for NP_058056.2

    Status: VALIDATED

    Source sequence(s)
    BC048858, CJ305435, CN716759
    Consensus CDS
    CCDS24986.1
    UniProtKB/Swiss-Prot
    O35851, Q7TPV4, Q80Y66, Q8R4X2, Q99KP0
    UniProtKB/TrEMBL
    A0JLT5, Q3U2W2
    Related
    ENSMUSP00000044827.6, ENSMUST00000045633.6
    Conserved Domains (3) summary
    pfam04931
    Location:70835
    DNA_pol_phi; DNA polymerase phi
    pfam05104
    Location:11431289
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    pfam15304
    Location:11931340
    AKAP2_C; A-kinase anchor protein 2 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72332153..72342596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)