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Osm oncostatin M [ Mus musculus (house mouse) ]

Gene ID: 18413, updated on 23-Dec-2018

Summary

Official Symbol
Osmprovided by MGI
Official Full Name
oncostatin Mprovided by MGI
Primary source
MGI:MGI:104749
See related
Ensembl:ENSMUSG00000058755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OncoM
Expression
Broad expression in spleen adult (RPKM 1.9), thymus adult (RPKM 1.8) and 15 other tissues See more
Orthologs

Genomic context

See Osm in Genome Data Viewer
Location:
11 A1; 11 2.94 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (4236785..4241026)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (4136788..4141029)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene predicted gene 11956 Neighboring gene leukemia inhibitory factor Neighboring gene predicted gene 11959

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
oncostatin-M receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of meiotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
oncostatin-M-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-17 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013365.2NP_001013383.1  oncostatin-M precursor

    See identical proteins and their annotated locations for NP_001013383.1

    Status: VALIDATED

    Source sequence(s)
    AL807825
    Consensus CDS
    CCDS24382.1
    UniProtKB/Swiss-Prot
    P53347
    Related
    ENSMUSP00000074708.2, ENSMUST00000075221.2
    Conserved Domains (2) summary
    pfam01291
    Location:43194
    LIF_OSM; LIF / OSM family
    pfam02956
    Location:191249
    TT_ORF1; TT viral orf 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    4236785..4241026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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