Format

Send to:

Choose Destination

DTYMK deoxythymidylate kinase [ Homo sapiens (human) ]

Gene ID: 1841, updated on 11-Jul-2021

Summary

Official Symbol
DTYMKprovided by HGNC
Official Full Name
deoxythymidylate kinaseprovided by HGNC
Primary source
HGNC:HGNC:3061
See related
Ensembl:ENSG00000168393 MIM:188345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC8; TMPK; TYMK; PP3731
Expression
Ubiquitous expression in bone marrow (RPKM 9.1), lymph node (RPKM 8.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DTYMK in Genome Data Viewer
Location:
2q37.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (241675747..241686815, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242615162..242626230, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 122 Neighboring gene THAP domain containing 4 Neighboring gene autophagy related 4B cysteine peptidase Neighboring gene inhibitor of growth family member 5 Neighboring gene D-2-hydroxyglutarate dehydrogenase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44192, MGC198617

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thymidylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thymidylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables uridylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in dTDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dTTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dTTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in dUDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleoside diphosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estrogen IEA
Inferred from Electronic Annotation
more info
 
involved_in thymidine biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
thymidylate kinase
Names
dTMP kinase
deoxythymidylate kinase (thymidylate kinase)
NP_001158503.1
NP_001307831.1
NP_001307832.1
NP_001307833.1
NP_001307834.1
NP_036277.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165031.2NP_001158503.1  thymidylate kinase isoform 2

    See identical proteins and their annotated locations for NP_001158503.1

    Status: VALIDATED

    Source sequence(s)
    AA446104, AK223434, BC171902
    UniProtKB/Swiss-Prot
    P23919
    UniProtKB/TrEMBL
    Q53F55
    Conserved Domains (2) summary
    PLN02924
    Location:2187
    PLN02924; thymidylate kinase
    pfam02223
    Location:11167
    Thymidylate_kin; Thymidylate kinase
  2. NM_001320902.2NP_001307831.1  thymidylate kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA446104, AK223434, CN356277, CX166352
    UniProtKB/TrEMBL
    Q53F55
    Conserved Domains (2) summary
    PLN02924
    Location:2168
    PLN02924; thymidylate kinase
    pfam02223
    Location:11148
    Thymidylate_kin; Thymidylate kinase
  3. NM_001320903.2NP_001307832.1  thymidylate kinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA446104, AK223434, BC171902, CX166352
    UniProtKB/Swiss-Prot
    P23919
    UniProtKB/TrEMBL
    Q53F55
    Conserved Domains (1) summary
    cl17190
    Location:278
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  4. NM_001320904.2NP_001307833.1  thymidylate kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AA427388, AA446104, AK223434, CX166352
    UniProtKB/TrEMBL
    Q53F55
    Related
    ENSP00000408939.1, ENST00000445261.5
    Conserved Domains (2) summary
    PLN02924
    Location:2192
    PLN02924; thymidylate kinase
    pfam02223
    Location:11172
    Thymidylate_kin; Thymidylate kinase
  5. NM_001320905.2NP_001307834.1  thymidylate kinase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AA446104, AC133528, AK223434, BF951595, CX166352
    UniProtKB/TrEMBL
    Q53F55
    Conserved Domains (3) summary
    PLN02924
    Location:2250
    PLN02924; thymidylate kinase
    pfam02223
    Location:11230
    Thymidylate_kin; Thymidylate kinase
    pfam13900
    Location:84119
    GVQW; Putative domain of unknown function
  6. NM_012145.4NP_036277.2  thymidylate kinase isoform 1

    See identical proteins and their annotated locations for NP_036277.2

    Status: VALIDATED

    Source sequence(s)
    AA446104, BC147006
    Consensus CDS
    CCDS2552.1
    UniProtKB/Swiss-Prot
    P23919
    UniProtKB/TrEMBL
    Q6FGU2
    Related
    ENSP00000304802.2, ENST00000305784.7
    Conserved Domains (1) summary
    PLN02924
    Location:2211
    PLN02924; thymidylate kinase

RNA

  1. NR_033255.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AW273041, BC171903, BQ021114
    Related
    ENST00000400770.6
  2. NR_135492.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA446104, AK223434, CN356277, CX166352

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    241675747..241686815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center