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DTYMK deoxythymidylate kinase [ Homo sapiens (human) ]

Gene ID: 1841, updated on 5-Nov-2017
Official Symbol
DTYMKprovided by HGNC
Official Full Name
deoxythymidylate kinaseprovided by HGNC
Primary source
HGNC:HGNC:3061
See related
Ensembl:ENSG00000168393 MIM:188345; Vega:OTTHUMG00000133409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC8; TMPK; TYMK; PP3731
Expression
Ubiquitous expression in bone marrow (RPKM 9.1), lymph node (RPKM 8.0) and 25 other tissues See more
Orthologs
Location:
2q37.3
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (241675742..241686968, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242615157..242626383, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 122 Neighboring gene THAP domain containing 4 Neighboring gene autophagy related 4B cysteine peptidase Neighboring gene inhibitor of growth family member 5 Neighboring gene D-2-hydroxyglutarate dehydrogenase

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ44192, MGC198617

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
nucleoside phosphate kinase activity EXP
Inferred from Experiment
more info
PubMed 
thymidylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
uridylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
cell cycle TAS
Traceable Author Statement
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
dTDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
dTTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
dTTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dUDP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
nucleotide phosphorylation IEA
Inferred from Electronic Annotation
more info
 
response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
response to estrogen IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
thymidylate kinase
Names
dTMP kinase
deoxythymidylate kinase (thymidylate kinase)
NP_001158503.1
NP_001307831.1
NP_001307832.1
NP_001307833.1
NP_001307834.1
NP_036277.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165031.1NP_001158503.1  thymidylate kinase isoform 2

    See identical proteins and their annotated locations for NP_001158503.1

    Status: VALIDATED

    Source sequence(s)
    AA446104, AK223434, BC171902, BQ021114, CX166352
    UniProtKB/Swiss-Prot
    P23919
    UniProtKB/TrEMBL
    Q53F55
    Conserved Domains (2) summary
    PLN02924
    Location:2187
    PLN02924; thymidylate kinase
    pfam02223
    Location:11167
    Thymidylate_kin; Thymidylate kinase
  2. NM_001320902.1NP_001307831.1  thymidylate kinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AA446104, AK223434, BQ021114, CN356277, CX166352
    UniProtKB/TrEMBL
    Q53F55
    Conserved Domains (2) summary
    PLN02924
    Location:2168
    PLN02924; thymidylate kinase
    pfam02223
    Location:11148
    Thymidylate_kin; Thymidylate kinase
  3. NM_001320903.1NP_001307832.1  thymidylate kinase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA446104, AK223434, BC171902, BQ021114, CX166352
    UniProtKB/Swiss-Prot
    P23919
    UniProtKB/TrEMBL
    Q53F55
    Conserved Domains (1) summary
    cl17190
    Location:278
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  4. NM_001320904.1NP_001307833.1  thymidylate kinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AA427388, AA446104, AK223434, BQ021114, CX166352
    UniProtKB/TrEMBL
    Q53F55
    Related
    ENSP00000408939.1, OTTHUMP00000200145, ENST00000445261.5, OTTHUMT00000322963
    Conserved Domains (2) summary
    PLN02924
    Location:2192
    PLN02924; thymidylate kinase
    pfam02223
    Location:11172
    Thymidylate_kin; Thymidylate kinase
  5. NM_001320905.1NP_001307834.1  thymidylate kinase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AA446104, AC133528, AK223434, BF951595, BQ021114, CX166352
    UniProtKB/TrEMBL
    Q53F55
    Conserved Domains (3) summary
    PLN02924
    Location:2250
    PLN02924; thymidylate kinase
    pfam02223
    Location:11230
    Thymidylate_kin; Thymidylate kinase
    pfam13900
    Location:84119
    GVQW; Putative domain of unknown function
  6. NM_012145.3NP_036277.2  thymidylate kinase isoform 1

    See identical proteins and their annotated locations for NP_036277.2

    Status: VALIDATED

    Source sequence(s)
    AA446104, BC147006, BQ021114, CX166352
    Consensus CDS
    CCDS2552.1
    UniProtKB/Swiss-Prot
    P23919
    UniProtKB/TrEMBL
    Q6FGU2
    Related
    ENSP00000304802.2, OTTHUMP00000164604, ENST00000305784.6, OTTHUMT00000257266
    Conserved Domains (1) summary
    PLN02924
    Location:2211
    PLN02924; thymidylate kinase

RNA

  1. NR_033255.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AW273041, BC171903, BQ021114, CX166352
    Related
    ENST00000400770.6, OTTHUMT00000322959
  2. NR_135492.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA446104, AK223434, BQ021114, CN356277, CX166352

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

    Range
    241675742..241686968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    242621221..242632448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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