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Orc1 origin recognition complex, subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 18392, updated on 12-May-2024

Summary

Official Symbol
Orc1provided by MGI
Official Full Name
origin recognition complex, subunit 1provided by MGI
Primary source
MGI:MGI:1328337
See related
Ensembl:ENSMUSG00000028587 AllianceGenome:MGI:1328337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Orc1l; MmORC1
Summary
Predicted to enable DNA replication origin binding activity and chromatin binding activity. Predicted to be involved in DNA replication initiation; positive regulation of smooth muscle cell proliferation; and regulation of cell cycle process. Predicted to act upstream of or within DNA replication. Predicted to be located in nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in liver and submandibular gland. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 4.8), liver E14.5 (RPKM 4.6) and 16 other tissues See more
Orthologs
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Genomic context

See Orc1 in Genome Data Viewer
Location:
4 C7; 4 50.64 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108436651..108472030)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (108575705..108616030)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene terminal uridylyl transferase 4 Neighboring gene predicted gene, 22345 Neighboring gene STARR-positive B cell enhancer ABC_E1036 Neighboring gene PRP38 pre-mRNA processing factor 38 (yeast) domain containing A Neighboring gene predicted gene 12743 Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene zinc finger, FYVE domain containing 9 Neighboring gene ribosomal protein L9 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication TAS
Traceable Author Statement
more info
PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of G0 to G1 transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear origin of replication recognition complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of origin recognition complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
origin recognition complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011015.2NP_035145.2  origin recognition complex subunit 1

    See identical proteins and their annotated locations for NP_035145.2

    Status: VALIDATED

    Source sequence(s)
    AJ003133, AK141741, AK164035
    Consensus CDS
    CCDS18453.1
    UniProtKB/Swiss-Prot
    A2A8R3, Q9Z1N2
    UniProtKB/TrEMBL
    Q8C9G3
    Related
    ENSMUSP00000099805.4, ENSMUST00000102744.4
    Conserved Domains (5) summary
    TIGR02928
    Location:474806
    TIGR02928; orc1/cdc6 family replication initiation protein
    pfam09079
    Location:757830
    Cdc6_C; CDC6, C terminal
    pfam13191
    Location:483533
    AAA_16; AAA ATPase domain
    cl02608
    Location:43169
    BAH; BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
    cl21455
    Location:509654
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    108436651..108472030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001014425.1: Suppressed sequence

    Description
    NM_001014425.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.