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DTNB dystrobrevin beta [ Homo sapiens (human) ]

Gene ID: 1838, updated on 6-Sep-2020

Summary

Official Symbol
DTNBprovided by HGNC
Official Full Name
dystrobrevin betaprovided by HGNC
Primary source
HGNC:HGNC:3058
See related
Ensembl:ENSG00000138101 MIM:602415
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in salivary gland (RPKM 3.0), brain (RPKM 2.3) and 25 other tissues See more
Orthologs

Genomic context

See DTNB in Genome Data Viewer
Location:
2p23.3
Exon count:
28
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (25377243..25673577, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (25600067..25896516, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1381 Neighboring gene DNA methyltransferase 3 alpha Neighboring gene microRNA 1301 Neighboring gene DTNB antisense RNA 1 Neighboring gene uncharacterized LOC105374332 Neighboring gene ASXL transcriptional regulator 2 Neighboring gene tropomyosin 3 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
GeneReviews: Not available
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.
GeneReviews: Not available
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
GeneReviews: Not available
Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
GeneReviews: Not available
Many sequence variants affecting diversity of adult human height.
GeneReviews: Not available
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17163, MGC57126

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
synaptic signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dystrobrevin beta
Names
DTN-B
beta-dystrobrevin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256303.2NP_001243232.1  dystrobrevin beta isoform 6

    Status: REVIEWED

    Source sequence(s)
    AK300019, BC016655, DB460644, Y15722
    Consensus CDS
    CCDS74496.1
    UniProtKB/Swiss-Prot
    O60941
    UniProtKB/TrEMBL
    B7Z6A9, E7EVB6
    Related
    ENSP00000288642.9, ENST00000288642.12
    Conserved Domains (4) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam13874
    Location:434519
    Nup54; Nucleoporin complex subunit 54
  2. NM_001256304.3NP_001243233.1  dystrobrevin beta isoform 7

    See identical proteins and their annotated locations for NP_001243233.1

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    UniProtKB/TrEMBL
    Q1I0L3
    Conserved Domains (4) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam13874
    Location:434519
    Nup54; Nucleoporin complex subunit 54
  3. NM_001256308.2NP_001243237.1  dystrobrevin beta isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC019144, AK301386, BC016655
    Consensus CDS
    CCDS58702.1
    UniProtKB/Swiss-Prot
    O60941
    Related
    ENSP00000444463.1, ENST00000496972.6
    Conserved Domains (4) summary
    cd02334
    Location:184232
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:183
    EF-hand_2; EF hand
    pfam09069
    Location:87175
    EF-hand_3; EF-hand
    pfam13874
    Location:377462
    Nup54; Nucleoporin complex subunit 54
  4. NM_001320932.2NP_001307861.1  dystrobrevin beta isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC012074, AC104699, AK225724, BC016655, DB460644
    UniProtKB/Swiss-Prot
    O60941
    Conserved Domains (3) summary
    cd02334
    Location:3785
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:128
    EF-hand_3; EF-hand
    pfam13874
    Location:230315
    Nup54; Nucleoporin complex subunit 54
  5. NM_001320933.2NP_001307862.1  dystrobrevin beta isoform 10

    Status: REVIEWED

    Source sequence(s)
    BC016655, BU846095, BX389926, DB460644, HY302507
    Consensus CDS
    CCDS82428.1
    UniProtKB/Swiss-Prot
    O60941
    UniProtKB/TrEMBL
    E9PEY4
    Related
    ENSP00000385784.1, ENST00000407186.5
    Conserved Domains (4) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam13874
    Location:404489
    Nup54; Nucleoporin complex subunit 54
  6. NM_001320934.2NP_001307863.1  dystrobrevin beta isoform 11

    Status: REVIEWED

    Source sequence(s)
    AF022728, BC016655, BU846095, BX389926, DB460644, HY302507
    UniProtKB/Swiss-Prot
    O60941
    Conserved Domains (4) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam13874
    Location:404487
    Nup54; Nucleoporin complex subunit 54
  7. NM_001320935.2NP_001307864.1  dystrobrevin beta isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC104699, AK294174, BC016655, DB460644
    UniProtKB/Swiss-Prot
    O60941
    UniProtKB/TrEMBL
    B7Z202
    Conserved Domains (3) summary
    cd02334
    Location:3785
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:128
    EF-hand_3; EF-hand
    pfam13874
    Location:230315
    Nup54; Nucleoporin complex subunit 54
  8. NM_001320936.2NP_001307865.1  dystrobrevin beta isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC012074, AF022728, DB460644
    UniProtKB/Swiss-Prot
    O60941
    Conserved Domains (5) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam04012
    Location:347528
    PspA_IM30; PspA/IM30 family
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:438525
    YlqD; YlqD protein
  9. NM_001320937.2NP_001307866.1  dystrobrevin beta isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC019144, AI608704, AL555818, DB460644
    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
  10. NM_001351381.2NP_001338310.1  dystrobrevin beta isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (4) summary
    cd02334
    Location:94142
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd15901
    Location:433
    EFh_DMD_DYTN_DTN; EF-hand-like motif [structural motif]
    cl07621
    Location:467
    EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    cl25732
    Location:260350
    SMC_N; RecF/RecN/SMC N terminal domain
  11. NM_001351382.2NP_001338311.1  dystrobrevin beta isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25602
    Location:401495
    DUF3552; Domain of unknown function (DUF3552)
  12. NM_001351383.2NP_001338312.1  dystrobrevin beta isoform 17

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25732
    Location:401503
    SMC_N; RecF/RecN/SMC N terminal domain
  13. NM_001351384.2NP_001338313.1  dystrobrevin beta isoform 18

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl27210
    Location:427521
    Mnd1; Mnd1 family
  14. NM_001351385.2NP_001338314.1  dystrobrevin beta isoform 19

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (2) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
  15. NM_001351386.2NP_001338315.1  dystrobrevin beta isoform 20

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl27210
    Location:397491
    Mnd1; Mnd1 family
  16. NM_001351387.2NP_001338316.1  dystrobrevin beta isoform 21

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25732
    Location:401503
    SMC_N; RecF/RecN/SMC N terminal domain
  17. NM_001351388.2NP_001338317.1  dystrobrevin beta isoform 22

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25602
    Location:431525
    DUF3552; Domain of unknown function (DUF3552)
  18. NM_001351389.2NP_001338318.1  dystrobrevin beta isoform 23

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC019144, AC104699
    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25602
    Location:401495
    DUF3552; Domain of unknown function (DUF3552)
  19. NM_001351390.2NP_001338319.1  dystrobrevin beta isoform 24

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl25602
    Location:401495
    DUF3552; Domain of unknown function (DUF3552)
  20. NM_001351391.2NP_001338320.1  dystrobrevin beta isoform 25

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl27210
    Location:397491
    Mnd1; Mnd1 family
  21. NM_001351392.2NP_001338321.1  dystrobrevin beta isoform 26

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (4) summary
    cd02334
    Location:94142
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd15901
    Location:433
    EFh_DMD_DYTN_DTN; EF-hand-like motif [structural motif]
    cl07621
    Location:467
    EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    cl25723
    Location:257346
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  22. NM_001351393.2NP_001338322.1  dystrobrevin beta isoform 27

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (4) summary
    cd02334
    Location:94142
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd15901
    Location:433
    EFh_DMD_DYTN_DTN; EF-hand-like motif [structural motif]
    cl07621
    Location:467
    EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    cl25723
    Location:257346
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
  23. NM_001351394.2NP_001338323.1  dystrobrevin beta isoform 28

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (4) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16250
    Location:54214
    EFh_DTNB; EF-hand-like motif found in beta-dystrobrevin
    cl25723
    Location:434531
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cl25917
    Location:346518
    Exonuc_VII_L; Exonuclease VII, large subunit
  24. NM_001351395.2NP_001338324.1  dystrobrevin beta isoform 29

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699
    Conserved Domains (2) summary
    cl25732
    Location:10216
    SMC_N; RecF/RecN/SMC N terminal domain
    cl27210
    Location:122216
    Mnd1; Mnd1 family
  25. NM_021907.5NP_068707.1  dystrobrevin beta isoform 1

    See identical proteins and their annotated locations for NP_068707.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF022728, DB460644
    Consensus CDS
    CCDS46237.1
    UniProtKB/Swiss-Prot
    O60941
    Related
    ENSP00000384084.3, ENST00000406818.7
    Conserved Domains (4) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:438525
    YlqD; YlqD protein
  26. NM_033147.4NP_149159.2  dystrobrevin beta isoform 2

    See identical proteins and their annotated locations for NP_149159.2

    Status: REVIEWED

    Source sequence(s)
    AF022728, BC016655, DB460644
    Consensus CDS
    CCDS46235.1
    UniProtKB/Swiss-Prot
    O60941
    Related
    ENSP00000385482.3, ENST00000404103.7
    Conserved Domains (4) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam13874
    Location:434517
    Nup54; Nucleoporin complex subunit 54
  27. NM_033148.4NP_149160.1  dystrobrevin beta isoform 3

    See identical proteins and their annotated locations for NP_149160.1

    Status: REVIEWED

    Source sequence(s)
    DB460644, Y12712
    Consensus CDS
    CCDS46234.1
    UniProtKB/Swiss-Prot
    O60941
    Related
    ENSP00000384767.3, ENST00000407038.7
    Conserved Domains (4) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam13874
    Location:404487
    Nup54; Nucleoporin complex subunit 54
  28. NM_183360.3NP_899204.1  dystrobrevin beta isoform 4

    See identical proteins and their annotated locations for NP_899204.1

    Status: REVIEWED

    Source sequence(s)
    BC016655, BC049366, DB460644, Y12712
    Consensus CDS
    CCDS46236.1
    UniProtKB/Swiss-Prot
    O60941
    Related
    ENSP00000385193.3, ENST00000407661.7
    Conserved Domains (4) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:438525
    YlqD; YlqD protein
  29. NM_183361.3NP_899205.1  dystrobrevin beta isoform 5

    See identical proteins and their annotated locations for NP_899205.1

    Status: REVIEWED

    Source sequence(s)
    BC016655, DB460644
    Consensus CDS
    CCDS46233.1
    UniProtKB/Swiss-Prot
    O60941
    Related
    ENSP00000384787.1, ENST00000405222.5
    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd16244
    Location:54214
    EFh_DTN; EF-hand-like motif found in dystrobrevins and similar proteins
    cl27210
    Location:397491
    Mnd1; Mnd1 family

RNA

  1. NR_147180.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010150, AC012074, AC019144, AC104699

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    25377243..25673577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003545.2XP_016859034.1  dystrobrevin beta isoform X19

  2. XM_017003543.2XP_016859032.1  dystrobrevin beta isoform X18

  3. XM_024452743.1XP_024308511.1  dystrobrevin beta isoform X17

    Conserved Domains (3) summary
    cd02334
    Location:3785
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cl07621
    Location:128
    EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    cl25602
    Location:227321
    DUF3552; Domain of unknown function (DUF3552)
  4. XM_024452742.1XP_024308510.1  dystrobrevin beta isoform X16

    Conserved Domains (3) summary
    cd02334
    Location:3785
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cl07621
    Location:128
    EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    cl25732
    Location:227329
    SMC_N; RecF/RecN/SMC N terminal domain
  5. XM_017003539.2XP_016859028.1  dystrobrevin beta isoform X14

  6. XM_024452740.1XP_024308508.1  dystrobrevin beta isoform X15

    Conserved Domains (5) summary
    cd02334
    Location:94142
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cd15901
    Location:433
    EFh_DMD_DYTN_DTN; EF-hand-like motif [structural motif]
    cl07621
    Location:467
    EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    cl25723
    Location:287368
    KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
    cl25917
    Location:199379
    Exonuc_VII_L; Exonuclease VII, large subunit
  7. XM_017003538.2XP_016859027.1  dystrobrevin beta isoform X13

  8. XM_011532681.2XP_011530983.1  dystrobrevin beta isoform X12

    Conserved Domains (3) summary
    cd02334
    Location:94142
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:485
    EF-hand_3; EF-hand
    pfam11068
    Location:291378
    YlqD; YlqD protein
  9. XM_011532680.3XP_011530982.1  dystrobrevin beta isoform X11

    Conserved Domains (3) summary
    cd02334
    Location:94142
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:485
    EF-hand_3; EF-hand
    pfam10211
    Location:348386
    Ax_dynein_light; Axonemal dynein light chain
  10. XM_017003544.2XP_016859033.1  dystrobrevin beta isoform X19

  11. XM_017003542.2XP_016859031.1  dystrobrevin beta isoform X18

  12. XM_024452741.1XP_024308509.1  dystrobrevin beta isoform X16

    Conserved Domains (3) summary
    cd02334
    Location:3785
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cl07621
    Location:128
    EFh_DMD_DYTN_DTN; EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
    cl25732
    Location:227329
    SMC_N; RecF/RecN/SMC N terminal domain
  13. XM_017003529.1XP_016859018.1  dystrobrevin beta isoform X7

  14. XM_011532676.1XP_011530978.1  dystrobrevin beta isoform X6

    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
  15. XM_011532675.1XP_011530977.1  dystrobrevin beta isoform X5

    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
  16. XM_011532673.1XP_011530975.1  dystrobrevin beta isoform X3

    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
  17. XM_011532674.1XP_011530976.1  dystrobrevin beta isoform X4

    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
  18. XM_011532671.1XP_011530973.1  dystrobrevin beta isoform X1

    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
  19. XM_011532677.2XP_011530979.1  dystrobrevin beta isoform X9

    Conserved Domains (4) summary
    cd02334
    Location:184232
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:183
    EF-hand_2; EF hand
    pfam09069
    Location:87175
    EF-hand_3; EF-hand
    pfam10211
    Location:438476
    Ax_dynein_light; Axonemal dynein light chain
  20. XM_017003530.2XP_016859019.1  dystrobrevin beta isoform X8

  21. XM_011532672.2XP_011530974.1  dystrobrevin beta isoform X2

    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
  22. XM_011532679.1XP_011530981.1  dystrobrevin beta isoform X10

    Conserved Domains (3) summary
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16140
    EF-hand_2; EF hand
    pfam09069
    Location:144232
    EF-hand_3; EF-hand

RNA

  1. XR_001738659.2 RNA Sequence

  2. XR_939672.3 RNA Sequence

    Related
    ENST00000398951.6
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