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cyp-33E1 CYtochrome P450 family [ Caenorhabditis elegans ]

Gene ID: 183602, updated on 24-Jul-2025
Official Symbol
cyp-33E1
Official Full Name
CYtochrome P450 family
Primary source
WormBase:WBGene00016768
Locus tag
CELE_C49C8.4
See related
AllianceGenome:WB:WBGene00016768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); drug dependence (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and liver disease (multiple). Orthologous to several human genes including CYP2A7 (cytochrome P450 family 2 subfamily A member 7); CYP2B6 (cytochrome P450 family 2 subfamily B member 6); and CYP2C18 (cytochrome P450 family 2 subfamily C member 18). [provided by Alliance of Genome Resources, Apr 2025]
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Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (8645521..8648602, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Diacylglycerol kinase Neighboring gene Protein with signal anchor Neighboring gene HTH CENPB-type domain-containing protein Neighboring gene ncRNA Neighboring gene Fibrinogen C-terminal domain-containing protein Neighboring gene TMhelix containing protein

Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Organ-specific electrophile responsivity mapping in live C. elegans. Liu J, et al. Cell, 2024 Dec 26. PMID 39504959
  2. Caenorhabditis elegans CYP33 Family in Eicosanoid Regulation, Xenobiotic Metabolism, Nanotoxicity and Spermatogenesis. Lim SYM, et al. J Appl Toxicol, 2025 May. PMID 39367649
  3. Development and evaluation of an in vivo assay in Caenorhabditis elegans for screening of compounds for their effect on cytochrome P450 expression. Chakrapani BP, et al. J Biosci, 2008 Jun. PMID 18535361
  4. Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans. Kulas J, et al. Arch Biochem Biophys, 2008 Apr 1. PMID 18282462
  5. A monoclonal antibody toolkit for C. elegans. Hadwiger G, et al. PLoS One, 2010 Apr 13. PMID 20405020, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Preferred Names
CYtochrome P450 family
NP_501480.2
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8645521..8648602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069079.6 → NP_501480.2  CYtochrome P450 family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501480.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q27482
    Conserved Domains (1) summary
    pfam00067
    Location:49 → 490
    p450; Cytochrome P450
Nucleotide Protein
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