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SLC26A2 solute carrier family 26 member 2 [ Homo sapiens (human) ]

Gene ID: 1836, updated on 9-Feb-2020

Summary

Official Symbol
SLC26A2provided by HGNC
Official Full Name
solute carrier family 26 member 2provided by HGNC
Primary source
HGNC:HGNC:10994
See related
Ensembl:ENSG00000155850 MIM:606718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DTD; EDM4; DTDST; MST153; D5S1708; MSTP157
Summary
The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 149.1), adrenal (RPKM 20.2) and 3 other tissues See more
Orthologs

Genomic context

See SLC26A2 in Genome Data Viewer
Location:
5q32
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (149960758..149987400)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149340300..149366963)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene PPARG coactivator 1 beta Neighboring gene NFE2L2 motif-containing MPRA enhancer 202 Neighboring gene phosphodiesterase 6A Neighboring gene MFF pseudogene 2 Neighboring gene tigger transposable element derived 6 Neighboring gene HMG-box containing 3 Neighboring gene ribosomal protein S20 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
anion:anion antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process TAS
Traceable Author Statement
more info
 
bicarbonate transport IEA
Inferred from Electronic Annotation
more info
 
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ion transport TAS
Traceable Author Statement
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
oxalate transport IEA
Inferred from Electronic Annotation
more info
 
sulfate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sulfate transporter
Names
diastrophic dysplasia protein
solute carrier family 26 (anion exchanger), member 2
solute carrier family 26 (sulfate transporter), member 2
sulfate anion transporter 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007147.2 RefSeqGene

    Range
    1855..28518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_684

mRNA and Protein(s)

  1. NM_000112.4NP_000103.2  sulfate transporter

    See identical proteins and their annotated locations for NP_000103.2

    Status: REVIEWED

    Source sequence(s)
    AC008427, AW089339, BC059390
    Consensus CDS
    CCDS4300.1
    UniProtKB/Swiss-Prot
    P50443
    Related
    ENSP00000286298.4, ENST00000286298.5
    Conserved Domains (2) summary
    cd06844
    Location:570707
    STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors
    TIGR00815
    Location:94715
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    149960758..149987400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009191.2XP_016864680.1  sulfate transporter isoform X1

    UniProtKB/Swiss-Prot
    P50443
    Conserved Domains (2) summary
    cd06844
    Location:570707
    STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors
    TIGR00815
    Location:94715
    sulP; high affinity sulphate transporter 1
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