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Ocln occludin [ Mus musculus (house mouse) ]

Gene ID: 18260, updated on 8-Feb-2024

Summary

Official Symbol
Oclnprovided by MGI
Official Full Name
occludinprovided by MGI
Primary source
MGI:MGI:106183
See related
Ensembl:ENSMUSG00000021638 AllianceGenome:MGI:106183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ocl
Summary
Predicted to enable protein domain specific binding activity. Involved in negative regulation of gene expression and tight junction organization. Located in several cellular components, including apical plasma membrane; apicolateral plasma membrane; and bicellular tight junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 9.2), colon adult (RPKM 5.6) and 22 other tissues See more
Orthologs
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Genomic context

See Ocln in Genome Data Viewer
Location:
13 D1; 13 53.23 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100633012..100689226, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100496504..100552718, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 13 Neighboring gene NLR family, apoptosis inhibitory protein 1 Neighboring gene general transcription factor II H, polypeptide 2 Neighboring gene STARR-positive B cell enhancer ABC_E1467 Neighboring gene predicted gene, 57598 Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene MARVEL (membrane-associating) domain containing 2 Neighboring gene predicted gene, 24261

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in tight junction ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
occludin
NP_001347465.1
NP_001347466.1
NP_001347467.1
NP_001347468.1
NP_032782.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360536.1NP_001347465.1  occludin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Consensus CDS
    CCDS26731.1
    UniProtKB/Swiss-Prot
    Q544A7, Q61146
    UniProtKB/TrEMBL
    B2RS24
    Related
    ENSMUSP00000022140.6, ENSMUST00000022140.12
    Conserved Domains (2) summary
    pfam01284
    Location:57261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain
  2. NM_001360537.1NP_001347466.1  occludin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Consensus CDS
    CCDS26731.1
    UniProtKB/Swiss-Prot
    Q544A7, Q61146
    UniProtKB/TrEMBL
    B2RS24
    Related
    ENSMUSP00000124849.2, ENSMUST00000160859.8
    Conserved Domains (2) summary
    pfam01284
    Location:57261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain
  3. NM_001360538.1NP_001347467.1  occludin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Consensus CDS
    CCDS26731.1
    UniProtKB/Swiss-Prot
    Q544A7, Q61146
    UniProtKB/TrEMBL
    B2RS24
    Conserved Domains (2) summary
    pfam01284
    Location:57261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain
  4. NM_001360539.1NP_001347468.1  occludin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158536
    UniProtKB/TrEMBL
    Q3UKZ5
    Related
    ENSMUSP00000125642.2, ENSMUST00000159459.8
    Conserved Domains (1) summary
    pfam07303
    Location:225324
    Occludin_ELL; Occludin homology domain
  5. NM_008756.2NP_032782.1  occludin isoform 1

    See identical proteins and their annotated locations for NP_032782.1

    Status: VALIDATED

    Source sequence(s)
    AK042576
    Consensus CDS
    CCDS26731.1
    UniProtKB/Swiss-Prot
    Q544A7, Q61146
    UniProtKB/TrEMBL
    B2RS24
    Related
    ENSMUSP00000065284.5, ENSMUST00000069756.11
    Conserved Domains (2) summary
    pfam01284
    Location:57261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100633012..100689226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)