Format

Send to:

Choose Destination

Ocln occludin [ Mus musculus (house mouse) ]

Gene ID: 18260, updated on 4-Jul-2019

Summary

Official Symbol
Oclnprovided by MGI
Official Full Name
occludinprovided by MGI
Primary source
MGI:MGI:106183
See related
Ensembl:ENSMUSG00000021638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ocl; AI503564
Expression
Broad expression in large intestine adult (RPKM 9.2), colon adult (RPKM 5.6) and 22 other tissues See more
Orthologs

Genomic context

See Ocln in Genome Data Viewer
Location:
13 D1; 13 53.23 cM
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (100496504..100553691, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (101267322..101322453, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 13 Neighboring gene NLR family, apoptosis inhibitory protein 1 Neighboring gene general transcription factor II H, polypeptide 2 Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene MARVEL (membrane-associating) domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
  • PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
    PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
 
response to interleukin-18 ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
occludin
NP_032782.1
XP_006517626.1
XP_006517627.1
XP_006517629.1
XP_011242936.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360536.1NP_001347465.1  occludin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Conserved Domains (2) summary
    pfam01284
    Location:58261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain
  2. NM_001360537.1NP_001347466.1  occludin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Conserved Domains (2) summary
    pfam01284
    Location:58261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain
  3. NM_001360538.1NP_001347467.1  occludin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Conserved Domains (2) summary
    pfam01284
    Location:58261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain
  4. NM_001360539.1NP_001347468.1  occludin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Conserved Domains (1) summary
    pfam07303
    Location:225324
    Occludin_ELL; Occludin homology domain
  5. NM_008756.2NP_032782.1  occludin isoform 1

    See identical proteins and their annotated locations for NP_032782.1

    Status: VALIDATED

    Source sequence(s)
    AK042576
    Consensus CDS
    CCDS26731.1
    UniProtKB/Swiss-Prot
    Q61146
    UniProtKB/TrEMBL
    B2RS24
    Related
    ENSMUSP00000065284.4, ENSMUST00000069756.10
    Conserved Domains (2) summary
    pfam01284
    Location:58261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    100496504..100553691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517563.3XP_006517626.1  occludin isoform X1

    UniProtKB/Swiss-Prot
    Q61146
    UniProtKB/TrEMBL
    B2RS24
    Related
    ENSMUSP00000022140.5, ENSMUST00000022140.11
    Conserved Domains (2) summary
    pfam01284
    Location:58261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain
  2. XM_006517564.3XP_006517627.1  occludin isoform X1

    UniProtKB/Swiss-Prot
    Q61146
    UniProtKB/TrEMBL
    B2RS24
    Conserved Domains (2) summary
    pfam01284
    Location:58261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain
  3. XM_011244634.2XP_011242936.1  occludin isoform X1

    UniProtKB/Swiss-Prot
    Q61146
    UniProtKB/TrEMBL
    B2RS24
    Related
    ENSMUSP00000124849.1, ENSMUST00000160859.7
    Conserved Domains (2) summary
    pfam01284
    Location:58261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain
  4. XM_006517566.2XP_006517629.1  occludin isoform X1

    See identical proteins and their annotated locations for XP_006517629.1

    UniProtKB/Swiss-Prot
    Q61146
    UniProtKB/TrEMBL
    B2RS24
    Conserved Domains (2) summary
    pfam01284
    Location:58261
    MARVEL; Membrane-associating domain
    pfam07303
    Location:419518
    Occludin_ELL; Occludin homology domain
Support Center