Nxn nucleoredoxin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nxnprovided by MGI
Official Full Name: nucleoredoxinprovided by MGI
Primary source: MGI:MGI:109331
See related: Ensembl:ENSMUSG00000020844 AllianceGenome:MGI:109331
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: l11Jus13
Summary: Enables thioredoxin-disulfide reductase activity. Involved in circulatory system development; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Acts upstream of or within in utero embryonic development. Located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; musculoskeletal system; and nervous system. Human ortholog(s) of this gene implicated in Robinow syndrome. Orthologous to human NXN (nucleoredoxin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 33.3), limb E14.5 (RPKM 23.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.92 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (76148052..76289967, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (76257226..76399141, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced exploratory behavior in neuronal nucleoredoxin knockout mice.
Title: Reduced exploratory behavior in neuronal nucleoredoxin knockout mice.
These results reveal a novel role of NRX in the regulation of PFK1 activity and in the balance between glycolysis and the pentose phosphate pathway.
Title: Nucleoredoxin regulates glucose metabolism via phosphofructokinase 1.
NRX retains a pool of inactive Dishevelled for robust activation of Wnt/beta-catenin signaling upon Wnt stimulation.
Title: Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein.
Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene
Title: Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene (88).
These data suggest a relationship between the Wnt-beta-catenin pathway and redox signalling through redox-sensitive association of NRX with Dvl.
Title: The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled.
formation of a complex between GST-nucleoredoxin, protein phosphatase 2A (PP2A) (C) and PP2A(D) was demonstrated by pull-down experiments
Title: Interaction of nucleoredoxin with protein phosphatase 2A.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm34 (e-PCR), detects polymorphism
- UniSTS:141636

D11Bhm35 (e-PCR), detects polymorphism
- UniSTS:141637

D11Bhm36 (e-PCR), detects polymorphism
- UniSTS:141638

NoName (e-PCR)
- UniSTS:236643

NoName (e-PCR)
- UniSTS:236647

D11Jcs11 (e-PCR), detects polymorphism
- UniSTS:461958

Homology

Homologs of the Nxn gene: The Nxn gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 491 organisms have orthologs with human gene Nxn
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-disulfide reductase (NAD(P)) activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin-disulfide reductase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables thioredoxin-disulfide reductase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular oxidant detoxification	IDA Inferred from Direct Assay more info	PubMed
involved_in circulatory system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nucleoredoxin

Names: protein Red-1

NP_032776.1

EC 1.8.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008750.5 → NP_032776.1 nucleoredoxin

See identical proteins and their annotated locations for NP_032776.1

Status: VALIDATED

Source sequence(s)

AI425633, AK075628, BC058244

Consensus CDS

CCDS25064.1

UniProtKB/Swiss-Prot

P97346, Q99KF3

UniProtKB/TrEMBL

A0A8C6HZJ8

Related

ENSMUSP00000021204.4, ENSMUST00000021204.4

Conserved Domains (3) summary

cd03009
Location:176 → 307

TryX_like_TryX_NRX; Tryparedoxin (TryX)-like family, TryX and nucleoredoxin (NRX) subfamily; TryX and NRX are thioredoxin (TRX)-like protein disulfide oxidoreductases that alter the redox state of target proteins via the reversible oxidation of an active center CXXC motif. ...

cd03071
Location:312 → 427

PDI_b'_NRX; PDIb' family, NRX subgroup, redox inactive TRX-like domain b'; composed of vertebrate nucleoredoxins (NRX). NRX is a 400-amino acid nuclear protein with one redox active TRX domain followed by one redox inactive TRX-like domain homologous to the b' ...

cl00388
Location:11 → 165

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold