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Nr4a2 nuclear receptor subfamily 4, group A, member 2 [ Mus musculus (house mouse) ]

Gene ID: 18227, updated on 14-Mar-2023

Summary

Official Symbol
Nr4a2provided by MGI
Official Full Name
nuclear receptor subfamily 4, group A, member 2provided by MGI
Primary source
MGI:MGI:1352456
See related
Ensembl:ENSMUSG00000026826 AllianceGenome:MGI:1352456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NOT; HZF-3; Nurr1; RNR-1; TINOR; TINUR
Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; glucocorticoid receptor binding activity; and protein heterodimerization activity. Involved in several processes, including cellular response to corticotropin-releasing hormone stimulus; dopaminergic neuron differentiation; and fat cell differentiation. Acts upstream of or within several processes, including dopamine biosynthetic process; nervous system development; and response to amphetamine. Located in nucleus. Is expressed in several structures, including alimentary system; ear; genitourinary system; integumental system; and nervous system. Used to study Parkinson's disease and schizophrenia. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 2.3), stomach adult (RPKM 2.3) and 23 other tissues See more
Orthologs
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Genomic context

See Nr4a2 in Genome Data Viewer
Location:
2 C1.1; 2 31.66 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (56996845..57014018, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (57106830..57124003, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33458 Neighboring gene microRNA 195b Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene expressed sequence BB557941 Neighboring gene RIKEN cDNA 4930555B11 gene Neighboring gene nuclear encoded tRNA alanine 8 (anticodon CGC)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear glucocorticoid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear glucocorticoid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to corticotropin-releasing hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to corticotropin-releasing hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to extracellular stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to extracellular stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within central nervous system neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within central nervous system projection neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopaminergic neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within general adaptation syndrome IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within habenula development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of dopamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of respiratory gaseous exchange IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to inorganic substance ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within response to insecticide ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nuclear receptor subfamily 4 group A member 2
Names
NUR-related factor 1
nur related protein 1
orphan nuclear receptor NURR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001139509.1NP_001132981.1  nuclear receptor subfamily 4 group A member 2

    See identical proteins and their annotated locations for NP_001132981.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AK087495, AK158607, BE864591, CJ059409
    Consensus CDS
    CCDS16043.1
    UniProtKB/Swiss-Prot
    O08690, Q06219
    UniProtKB/TrEMBL
    A0A6P5P0T5, A0A8C6IK15, Q3TYI4
    Related
    ENSMUSP00000108248.2, ENSMUST00000112629.8
    Conserved Domains (2) summary
    cd07071
    Location:361598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  2. NM_013613.2NP_038641.1  nuclear receptor subfamily 4 group A member 2

    See identical proteins and their annotated locations for NP_038641.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AK087495, BC137715, BE864591, CJ059409
    Consensus CDS
    CCDS16043.1
    UniProtKB/Swiss-Prot
    O08690, Q06219
    UniProtKB/TrEMBL
    A0A6P5P0T5, A0A8C6IK15, Q3TYI4
    Related
    ENSMUSP00000028166.3, ENSMUST00000028166.9
    Conserved Domains (2) summary
    cd07071
    Location:361598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    56996845..57014018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159386.1XP_036015279.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/Swiss-Prot
    O08690
    UniProtKB/TrEMBL
    A0A6P5P0T5, A0A8C6IK15, Q3TYI4
    Conserved Domains (2) summary
    cd07071
    Location:361598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  2. XM_036159387.1XP_036015280.1  nuclear receptor subfamily 4 group A member 2 isoform X2

    UniProtKB/TrEMBL
    A2AQQ8
    Related
    ENSMUSP00000108246.2, ENSMUST00000112627.2
    Conserved Domains (2) summary
    cd07071
    Location:298535
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:198272
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  3. XM_036159385.1XP_036015278.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/Swiss-Prot
    O08690
    UniProtKB/TrEMBL
    A0A6P5P0T5, A0A8C6IK15, Q3TYI4
    Conserved Domains (2) summary
    cd07071
    Location:361598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  4. XM_011239033.4XP_011237335.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    See identical proteins and their annotated locations for XP_011237335.1

    UniProtKB/Swiss-Prot
    O08690, Q06219
    UniProtKB/TrEMBL
    A0A6P5P0T5, A0A8C6IK15, Q3TYI4
    Conserved Domains (2) summary
    cd07071
    Location:361598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

RNA

  1. XR_003951343.2 RNA Sequence

    Related
    ENSMUST00000183542.8
  2. XR_004938834.1 RNA Sequence