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Nsg1 neuron specific gene family member 1 [ Mus musculus (house mouse) ]

Gene ID: 18196, updated on 5-Jan-2023

Summary

Official Symbol
Nsg1provided by MGI
Official Full Name
neuron specific gene family member 1provided by MGI
Primary source
MGI:MGI:109149
See related
Ensembl:ENSMUSG00000029126 AllianceGenome:MGI:109149
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p21; m234; Neep21
Summary
Predicted to enable clathrin light chain binding activity and signaling receptor binding activity. Involved in several processes, including amyloid precursor protein metabolic process; neurotransmitter receptor transport; and receptor recycling. Located in several cellular components, including glutamatergic synapse; late endosome; and lateral plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; peripheral nervous system ganglion; and sensory organ. Orthologous to human NSG1 (neuronal vesicle trafficking associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 286.0), cerebellum adult (RPKM 209.6) and 6 other tissues See more
Orthologs
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Genomic context

See Nsg1 in Genome Data Viewer
Location:
5 B3; 5 20.21 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (38294537..38317087, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (38137193..38159743, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40289 Neighboring gene syntaxin 18 Neighboring gene VISTA enhancer mm1165 Neighboring gene zinc finger and BTB domain containing 49 Neighboring gene Ly1 antibody reactive clone

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in amyloid precursor protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter receptor cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic neurotransmitter receptor cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in spontaneous synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport in synapse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal lumen ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic endosome ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic endosome ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neuronal vesicle trafficking-associated protein 1
Names
brain neuron cytoplasmic protein 1
neuron-enriched endosomal protein of 21 kDa
neuron-specific protein family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359090.1NP_001346019.1  neuronal vesicle trafficking-associated protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AC115931
    Consensus CDS
    CCDS19251.1
    UniProtKB/Swiss-Prot
    Q922E5
    UniProtKB/TrEMBL
    A0A8C6I531
    Conserved Domains (1) summary
    pfam06387
    Location:1180
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)
  2. NM_001359091.1NP_001346020.1  neuronal vesicle trafficking-associated protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC115931
    Consensus CDS
    CCDS19251.1
    UniProtKB/Swiss-Prot
    Q922E5
    UniProtKB/TrEMBL
    A0A8C6I531
    Conserved Domains (1) summary
    pfam06387
    Location:1180
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)
  3. NM_001359092.1NP_001346021.1  neuronal vesicle trafficking-associated protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC115931
    Consensus CDS
    CCDS19251.1
    UniProtKB/Swiss-Prot
    Q922E5
    UniProtKB/TrEMBL
    A0A8C6I531
    Related
    ENSMUSP00000144396.2, ENSMUST00000201363.4
    Conserved Domains (1) summary
    pfam06387
    Location:1180
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)
  4. NM_010942.4NP_035072.2  neuronal vesicle trafficking-associated protein 1

    See identical proteins and their annotated locations for NP_035072.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC115931, AK076451, AK148941
    Consensus CDS
    CCDS19251.1
    UniProtKB/Swiss-Prot
    Q62092, Q922E5
    UniProtKB/TrEMBL
    A0A8C6I531
    Related
    ENSMUSP00000031009.5, ENSMUST00000031009.8
    Conserved Domains (1) summary
    pfam06387
    Location:1180
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    38294537..38317087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)