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Nrxn2 neurexin II [ Mus musculus (house mouse) ]

Gene ID: 18190, updated on 23-Mar-2023

Summary

Official Symbol
Nrxn2provided by MGI
Official Full Name
neurexin IIprovided by MGI
Primary source
MGI:MGI:1096362
See related
Ensembl:ENSMUSG00000033768 AllianceGenome:MGI:1096362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0921; 6430591O13Rik
Summary
Enables several functions, including calcium channel regulator activity; cell adhesion molecule binding activity; and neuroligin family protein binding activity. Involved in postsynapse organization and signal transduction. Acts upstream of or within neurotransmitter secretion and synapse assembly. Part of protein-containing complex. Is expressed in several structures, including blood vessel; nervous system; and retina. Used to study autism spectrum disorder. Orthologous to human NRXN2 (neurexin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 41.2), frontal lobe adult (RPKM 37.4) and 7 other tissues See more
Orthologs
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Genomic context

See Nrxn2 in Genome Data Viewer
Location:
19 A; 19
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6468786..6583247)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6418756..6533217)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene muscle glycogen phosphorylase Neighboring gene RAS, guanyl releasing protein 2 Neighboring gene predicted gene 14965 Neighboring gene predicted gene, 52381 Neighboring gene solute carrier family 22 (organic anion/cation transporter), member 12 Neighboring gene predicted gene, 32245

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (7)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel regulator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables neuroligin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in adult behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chemical synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in gephyrin clustering involved in postsynaptic density assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuroligin clustering involved in postsynaptic membrane assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in postsynaptic density protein 95 clustering IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic membrane assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synapse assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vocal learning ISO
Inferred from Sequence Orthology
more info
 
involved_in vocalization behavior ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic membrane ISA
Inferred from Sequence Alignment
more info
PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
neurexin-2
Names
neurexin II alpha
neurexin II beta
neurexin-2-alpha
neurexin-2-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205234.2NP_001192163.1  neurexin-2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC167245
    Consensus CDS
    CCDS57132.1
    UniProtKB/TrEMBL
    E9PUM9
    Related
    ENSMUSP00000109089.2, ENSMUST00000113462.8
    Conserved Domains (5) summary
    smart00282
    Location:509659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:16281667
    Syndecan; Syndecan domain
    pfam02210
    Location:9391067
    Laminin_G_2; Laminin G domain
  2. NM_001205235.2NP_001192164.1  neurexin-2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC167245
    Consensus CDS
    CCDS57133.1
    UniProtKB/TrEMBL
    E9Q5N7
    Related
    ENSMUSP00000076424.7, ENSMUST00000077182.13
    Conserved Domains (5) summary
    smart00282
    Location:501651
    LamG; Laminin G domain
    cd00054
    Location:679712
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14281467
    Syndecan; Syndecan domain
    pfam02210
    Location:9311059
    Laminin_G_2; Laminin G domain
  3. NM_001369363.1NP_001356292.1  neurexin-2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC167245
    Consensus CDS
    CCDS89327.1
    UniProtKB/Swiss-Prot
    E9Q7X7
    Related
    ENSMUSP00000119762.2, ENSMUST00000137166.8
    Conserved Domains (6) summary
    smart00282
    Location:516666
    LamG; Laminin G domain
    PHA03247
    Location:14331630
    PHA03247; large tegument protein UL36; Provisional
    cd00054
    Location:694727
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:16351674
    Syndecan; Syndecan domain
    pfam02210
    Location:9461074
    Laminin_G_2; Laminin G domain
  4. NM_020253.4NP_064649.2  neurexin-2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC167245
    Consensus CDS
    CCDS89326.1
    UniProtKB/TrEMBL
    A0A494B8Y4
    Related
    ENSMUSP00000157405.2, ENSMUST00000236635.2
    Conserved Domains (5) summary
    smart00282
    Location:509659
    LamG; Laminin G domain
    cd00054
    Location:687720
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:28184
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam01034
    Location:14361475
    Syndecan; Syndecan domain
    pfam02210
    Location:9391067
    Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6468786..6583247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)