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dhcr-7 DeHydroCholesterol Reductase [ Caenorhabditis elegans ]

Gene ID: 181886, updated on 24-Apr-2022

Summary

Gene symbol
dhcr-7
Gene description
DeHydroCholesterol Reductase
Primary source
WormBase:WBGene00007126
Locus tag
CELE_B0250.9
See related
AllianceGenome:WB:WBGene00007126
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 7-dehydrocholesterol reductase activity and sterol delta7 reductase activity. Predicted to be involved in brassinosteroid biosynthetic process and cholesterol biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; Smith-Lemli-Opitz syndrome; and primary biliary cholangitis. Orthologous to several human genes including DHCR7 (7-dehydrocholesterol reductase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See dhcr-7 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (20480803..20485385, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein L8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class BC (class B-like) Neighboring gene Serpentine Receptor, class BC (class B-like)

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 7-dehydrocholesterol reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxidoreductase activity, acting on the CH-CH group of donors IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables sterol delta7 reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in brassinosteroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DeHydroCholesterol Reductase
NP_507941.2
  • Product from WormBase gene class dhcr;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20480803..20485385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075540.6NP_507941.2  DeHydroCholesterol Reductase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507941.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED82
    Conserved Domains (1) summary
    cl21511
    Location:81457
    PEMT; Phospholipid methyltransferase