Format

Send to:

Choose Destination

Nrl neural retina leucine zipper gene [ Mus musculus (house mouse) ]

Gene ID: 18185, updated on 3-Jun-2018
Official Symbol
Nrlprovided by MGI
Official Full Name
neural retina leucine zipper geneprovided by MGI
Primary source
MGI:MGI:102567
See related
Ensembl:ENSMUSG00000040632
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D14H14S46E
Summary
This gene encodes a member of the basic leucine zipper domain family of transcription factors. The encoded protein is preferentially expressed in the retina and is necessary for rod photoreceptor development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Low expression observed in reference dataset See more
Orthologs
See Nrl in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (55518978..55524981, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56137815..56143802, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene capping protein regulator and myosin 1 linker 3 Neighboring gene copine VI Neighboring gene phosphoenolpyruvate carboxykinase 2 (mitochondrial) Neighboring gene DDB1 and CUL4 associated factor 11

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
leucine zipper domain binding ISO
Inferred from Sequence Orthology
more info
 
promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
neural retina-specific leucine zipper protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136074.2NP_001129546.1  neural retina-specific leucine zipper protein

    See identical proteins and their annotated locations for NP_001129546.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC159002, AK044244, AK044316
    Consensus CDS
    CCDS27113.1
    UniProtKB/Swiss-Prot
    P54846
    UniProtKB/TrEMBL
    Q543Y0, Q8C8Y1
    Related
    ENSMUSP00000136445.1, ENSMUST00000178694.2
    Conserved Domains (2) summary
    cd14718
    Location:154223
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:67101
    Maf_N; Maf N-terminal region
  2. NM_001271916.1NP_001258845.1  neural retina-specific leucine zipper protein

    See identical proteins and their annotated locations for NP_001258845.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC159002, AK044244, AK044275
    Consensus CDS
    CCDS27113.1
    UniProtKB/Swiss-Prot
    P54846
    UniProtKB/TrEMBL
    Q543Y0, Q8C8Y1
    Related
    ENSMUSP00000054457.7, ENSMUST00000062232.14
    Conserved Domains (2) summary
    cd14718
    Location:154223
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:67101
    Maf_N; Maf N-terminal region
  3. NM_001271917.1NP_001258846.1  neural retina-specific leucine zipper protein

    See identical proteins and their annotated locations for NP_001258846.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC159002, AK044244, AK044316
    Consensus CDS
    CCDS27113.1
    UniProtKB/Swiss-Prot
    P54846
    UniProtKB/TrEMBL
    Q543Y0, Q8C8Y1
    Related
    ENSMUSP00000153933.1, ENSMUST00000228287.1
    Conserved Domains (2) summary
    cd14718
    Location:154223
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:67101
    Maf_N; Maf N-terminal region
  4. NM_008736.3NP_032762.1  neural retina-specific leucine zipper protein

    See identical proteins and their annotated locations for NP_032762.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC159002, AK044275
    Consensus CDS
    CCDS27113.1
    UniProtKB/Swiss-Prot
    P54846
    UniProtKB/TrEMBL
    Q543Y0
    Related
    ENSMUSP00000107035.1, ENSMUST00000111404.7
    Conserved Domains (2) summary
    cd14718
    Location:154223
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:67101
    Maf_N; Maf N-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    55518978..55524981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518688.1XP_006518751.1  neural retina-specific leucine zipper protein isoform X1

    Conserved Domains (1) summary
    cd14718
    Location:56125
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
Support Center