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Nrl neural retina leucine zipper gene [ Mus musculus (house mouse) ]

Gene ID: 18185, updated on 18-Apr-2024

Summary

Official Symbol
Nrlprovided by MGI
Official Full Name
neural retina leucine zipper geneprovided by MGI
Primary source
MGI:MGI:102567
See related
Ensembl:ENSMUSG00000040632 AllianceGenome:MGI:102567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D14H14S46E
Summary
This gene encodes a member of the basic leucine zipper domain family of transcription factors. The encoded protein is preferentially expressed in the retina and is necessary for rod photoreceptor development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

Location:
14 C3; 14 28.19 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55756973..55762438, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55518978..55524981, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene capping protein regulator and myosin 1 linker 3 Neighboring gene copine VI Neighboring gene STARR-positive B cell enhancer ABC_E10826 Neighboring gene STARR-positive B cell enhancer ABC_E5439 Neighboring gene phosphoenolpyruvate carboxykinase 2 (mitochondrial) Neighboring gene STARR-seq mESC enhancer starr_36772 Neighboring gene STARR-positive B cell enhancer ABC_E607 Neighboring gene DDB1 and CUL4 associated factor 11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (5)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neural retina-specific leucine zipper protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136074.3NP_001129546.1  neural retina-specific leucine zipper protein isoform 1

    See identical proteins and their annotated locations for NP_001129546.1

    Status: VALIDATED

    Source sequence(s)
    AC159002
    Consensus CDS
    CCDS27113.1
    UniProtKB/Swiss-Prot
    P54846
    UniProtKB/TrEMBL
    Q543Y0, Q8C8Y1
    Related
    ENSMUSP00000136445.2, ENSMUST00000178694.3
    Conserved Domains (2) summary
    cd14718
    Location:154223
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:67101
    Maf_N; Maf N-terminal region
  2. NM_001271916.2NP_001258845.1  neural retina-specific leucine zipper protein isoform 1

    See identical proteins and their annotated locations for NP_001258845.1

    Status: VALIDATED

    Source sequence(s)
    AC159002
    Consensus CDS
    CCDS27113.1
    UniProtKB/Swiss-Prot
    P54846
    UniProtKB/TrEMBL
    Q543Y0, Q8C8Y1
    Related
    ENSMUSP00000054457.8, ENSMUST00000062232.15
    Conserved Domains (2) summary
    cd14718
    Location:154223
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:67101
    Maf_N; Maf N-terminal region
  3. NM_001271917.2NP_001258846.1  neural retina-specific leucine zipper protein isoform 1

    See identical proteins and their annotated locations for NP_001258846.1

    Status: VALIDATED

    Source sequence(s)
    AC159002
    Consensus CDS
    CCDS27113.1
    UniProtKB/Swiss-Prot
    P54846
    UniProtKB/TrEMBL
    Q543Y0, Q8C8Y1
    Related
    ENSMUSP00000153933.2, ENSMUST00000228287.2
    Conserved Domains (2) summary
    cd14718
    Location:154223
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:67101
    Maf_N; Maf N-terminal region
  4. NM_001424498.1NP_001411427.1  neural retina-specific leucine zipper protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159002
  5. NM_001424499.1NP_001411428.1  neural retina-specific leucine zipper protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159002
  6. NM_008736.4NP_032762.1  neural retina-specific leucine zipper protein isoform 1

    See identical proteins and their annotated locations for NP_032762.1

    Status: VALIDATED

    Source sequence(s)
    AC159002
    Consensus CDS
    CCDS27113.1
    UniProtKB/Swiss-Prot
    P54846
    UniProtKB/TrEMBL
    Q543Y0, Q8C8Y1
    Related
    ENSMUSP00000107035.2, ENSMUST00000111404.8
    Conserved Domains (2) summary
    cd14718
    Location:154223
    bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    pfam08383
    Location:67101
    Maf_N; Maf N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55756973..55762438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)