U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nrg3 neuregulin 3 [ Mus musculus (house mouse) ]

Gene ID: 18183, updated on 5-Jan-2023

Summary

Official Symbol
Nrg3provided by MGI
Official Full Name
neuregulin 3provided by MGI
Primary source
MGI:MGI:1097165
See related
Ensembl:ENSMUSG00000041014 AllianceGenome:MGI:1097165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ska
Summary
Enables chemorepellent activity. Acts upstream of or within several processes, including intracellular signal transduction; mammary placode formation; and regulation of cell migration. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space and glutamatergic synapse. Is expressed in several structures, including epidermis; mammary gland primordium; nervous system; testis; and trunk mesenchyme. Used to study schizophrenia. Orthologous to human NRG3 (neuregulin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 4.1), frontal lobe adult (RPKM 3.3) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nrg3 in Genome Data Viewer
Location:
14; 14 B
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (38086093..39195045, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (38365102..39473235, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene crumbs homolog 1 pseudogene Neighboring gene predicted gene, 31456 Neighboring gene cytochrome c oxidase, subunit VIIc pseudogene Neighboring gene predicted gene, 53854 Neighboring gene neuregulin 3, opposite strand Neighboring gene predicted gene 20642 Neighboring gene predicted gene, 31606 Neighboring gene uncharacterized LOC432842 Neighboring gene potassium channel modulatory factor 1 pseudogene Neighboring gene RIKEN cDNA 1700109I08 gene Neighboring gene predicted gene, 35389

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemorepellent activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ERBB4 signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in ERBB4-ERBB4 signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chemorepulsion involved in interneuron migration from the subpallium to the cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mammary gland development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary placode formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
pro-neuregulin-3, membrane-bound isoform
Names
pro-NRG3
scaramanga

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190187.1NP_001177116.1  pro-neuregulin-3, membrane-bound isoform isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC109253, AC154426, CT025583, CT025629, CT030231
    Conserved Domains (2) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:354401
    Neuregulin; Neuregulin family
  2. NM_001190188.1NP_001177117.1  pro-neuregulin-3, membrane-bound isoform isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC109253, AC154426, CT025583, CT025629, CT030231
    Consensus CDS
    CCDS49450.1
    UniProtKB/TrEMBL
    E9Q396
    Related
    ENSMUSP00000129783.3, ENSMUST00000168810.9
    Conserved Domains (2) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:355402
    Neuregulin; Neuregulin family
  3. NM_008734.3NP_032760.1  pro-neuregulin-3, membrane-bound isoform isoform 1

    See identical proteins and their annotated locations for NP_032760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC109253, AC154426, CT025583, CT025629, CT030231
    Consensus CDS
    CCDS26954.1
    UniProtKB/Swiss-Prot
    O35181
    Related
    ENSMUSP00000136884.2, ENSMUST00000166968.9
    Conserved Domains (2) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional
    pfam02158
    Location:355402
    Neuregulin; Neuregulin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    38086093..39195045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158506.1XP_036014399.1  pro-neuregulin-3, membrane-bound isoform isoform X9

    Conserved Domains (1) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional
  2. XM_006518687.5XP_006518750.1  pro-neuregulin-3, membrane-bound isoform isoform X7

    Conserved Domains (2) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional
    COG5160
    Location:351563
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
  3. XM_036158505.1XP_036014398.1  pro-neuregulin-3, membrane-bound isoform isoform X4

    Conserved Domains (1) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional
  4. XM_030247684.2XP_030103544.1  pro-neuregulin-3, membrane-bound isoform isoform X5

    Conserved Domains (2) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional
    COG5160
    Location:351564
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
  5. XM_011244987.4XP_011243289.1  pro-neuregulin-3, membrane-bound isoform isoform X2

    Conserved Domains (1) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional
  6. XM_017315911.3XP_017171400.1  pro-neuregulin-3, membrane-bound isoform isoform X8

    UniProtKB/TrEMBL
    G3V023
    Related
    ENSMUSP00000134727.2, ENSMUST00000173780.2
    Conserved Domains (1) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional
  7. XM_006518686.5XP_006518749.1  pro-neuregulin-3, membrane-bound isoform isoform X6

    Conserved Domains (2) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional
    COG5160
    Location:352564
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
  8. XM_006518685.5XP_006518748.1  pro-neuregulin-3, membrane-bound isoform isoform X3

    Conserved Domains (1) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional
  9. XM_017315910.3XP_017171399.1  pro-neuregulin-3, membrane-bound isoform isoform X1

    Conserved Domains (1) summary
    PHA02887
    Location:280333
    PHA02887; EGF-like protein; Provisional