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sod-3 Superoxide dismutase [Mn] 2, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 181748, updated on 19-Aug-2018

Summary

Gene symbol
sod-3
Gene description
Superoxide dismutase [Mn] 2, mitochondrial
Primary source
WormBase:WBGene00004932
Locus tag
CELE_C08A9.1
Gene type
protein coding
RNA name
Superoxide dismutase [Mn] 2, mitochondrial
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See sod-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Sequence:
Chromosome: X; NC_003284.9 (17092768..17094097)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene SKN-1 Dependent Zygotic transcript

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Detoxification of Reactive Oxygen Species, organism-specific biosystem (from REACTOME)
    Detoxification of Reactive Oxygen Species, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
    Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
  • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
    Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
  • Longevity regulating pathway - worm, organism-specific biosystem (from KEGG)
    Longevity regulating pathway - worm, organism-specific biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
  • Longevity regulating pathway - worm, conserved biosystem (from KEGG)
    Longevity regulating pathway - worm, conserved biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
superoxide dismutase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide dismutase activity IDA
Inferred from Direct Assay
more info
PubMed 
superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
removal of superoxide radicals IMP
Inferred from Mutant Phenotype
more info
PubMed 
superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial respiratory chain supercomplex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Superoxide dismutase [Mn] 2, mitochondrial
NP_510764.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    17092768..17094097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078363.6NP_510764.1  Superoxide dismutase [Mn] 2, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510764.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41977
    Conserved Domains (3) summary
    PLN02471
    Location:5216
    PLN02471; superoxide dismutase [Mn]
    pfam00081
    Location:25106
    Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
    pfam02777
    Location:112212
    Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain
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