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aak-2 5'-AMP-activated protein kinase catalytic subunit alpha-2 [ Caenorhabditis elegans ]

Gene ID: 181727, updated on 2-Oct-2018

Summary

Gene symbol
aak-2
Gene description
5'-AMP-activated protein kinase catalytic subunit alpha-2
Primary source
WormBase:WBGene00020142
Locus tag
CELE_T01C8.1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See aak-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (16796089..16802850)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Probable aspartate aminotransferase, cytoplasmic Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Degenerin mec-4 Neighboring gene Adenylyl cyclase-associated protein

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the aak-2 gene: The aak-2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
AMP-activated protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dauer larval development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
5'-AMP-activated protein kinase catalytic subunit alpha-2
NP_001024868.1
  • Confirmed by transcript evidence
NP_510710.2
  • Confirmed by transcript evidence
NP_510711.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    16796089..16802850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078309.4NP_510710.2  5'-AMP-activated protein kinase catalytic subunit alpha-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510710.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95ZQ4
    Conserved Domains (4) summary
    cd12122
    Location:462624
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    smart00220
    Location:87339
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14336
    Location:356419
    UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
    cd14079
    Location:84339
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
  2. NM_078310.5NP_510711.2  5'-AMP-activated protein kinase catalytic subunit alpha-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510711.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95ZQ4
    Conserved Domains (4) summary
    cd12122
    Location:460622
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    smart00220
    Location:87339
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14336
    Location:356417
    UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
    cd14079
    Location:84339
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
  3. NM_001029697.3NP_001024868.1  5'-AMP-activated protein kinase catalytic subunit alpha-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024868.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95ZQ4
    Conserved Domains (4) summary
    cd12122
    Location:398560
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    smart00220
    Location:25277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14336
    Location:294355
    UBA_AID_AMPKalpha; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic alpha (AMPKalpha) subunits
    cd14079
    Location:22277
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
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