U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ctnnd2 catenin (cadherin associated protein), delta 2 [ Mus musculus (house mouse) ]

Gene ID: 18163, updated on 8-Jan-2023

Summary

Official Symbol
Ctnnd2provided by MGI
Official Full Name
catenin (cadherin associated protein), delta 2provided by MGI
Primary source
MGI:MGI:1195966
See related
Ensembl:ENSMUSG00000022240 AllianceGenome:MGI:1195966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nprap; Catnd2; neurojugin
Summary
Predicted to enable beta-catenin binding activity and cadherin binding activity. Acts upstream of or within learning; morphogenesis of a branching structure; and regulation of synaptic plasticity. Located in postsynaptic density. Is expressed in several structures, including central nervous system; future brain; lung; sensory organ; and spinal ganglion. Human ortholog(s) of this gene implicated in anxiety disorder; major depressive disorder; and schizophrenia. Orthologous to human CTNND2 (catenin delta 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 25.6), frontal lobe adult (RPKM 25.1) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ctnnd2 in Genome Data Viewer
Location:
15; 15 B2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (30172680..31029490)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (30172534..31029344)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene predicted gene, 26163 Neighboring gene predicted gene, 31953 Neighboring gene VISTA enhancer mm1400 Neighboring gene predicted gene, 41284 Neighboring gene predicted gene, 24487 Neighboring gene predicted gene, 31841 Neighboring gene RIKEN cDNA 9630009A06 gene Neighboring gene predicted gene, 53868 Neighboring gene RIKEN cDNA 4930430F21 gene Neighboring gene predicted gene, 32011

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
catenin delta-2
Names
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
neural plakophilin-related arm-repeat protein
neurojungin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355502.2NP_001342431.1  catenin delta-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC105408, AC110569, AC124675, AC124993, AC134414, AC139197
    Consensus CDS
    CCDS88745.1
    UniProtKB/TrEMBL
    B7ZNF6
    Related
    ENSMUSP00000154410.2, ENSMUST00000226119.2
    Conserved Domains (5) summary
    smart00185
    Location:577617
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:830871
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:548573
    ARM; armadillo repeat [structural motif]
    cl26464
    Location:256530
    Atrophin-1; Atrophin-1 family
    cl27106
    Location:546719
    PLN03200; cellulose synthase-interactive protein; Provisional
  2. NM_001411452.1NP_001398381.1  catenin delta-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC105408, AC110569, AC124675, AC134414, AC139197
  3. NM_001411453.1NP_001398382.1  catenin delta-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC105408, AC110569, AC124675, AC134414, AC139197
  4. NM_008729.3NP_032755.2  catenin delta-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC105408, AC110569, AC124675, AC124993, AC134414, AC139197
    Consensus CDS
    CCDS27405.1
    UniProtKB/Swiss-Prot
    O35927
    UniProtKB/TrEMBL
    E9QKH8, Q3U8L7
    Related
    ENSMUSP00000080427.6, ENSMUST00000081728.7
    Conserved Domains (3) summary
    cd00020
    Location:540662
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam17052
    Location:10501109
    CAF20; Cap associated factor
    sd00043
    Location:548573
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    30172680..31029490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520033.4XP_006520096.1  catenin delta-2 isoform X1

    Conserved Domains (5) summary
    smart00185
    Location:486526
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:455628
    PLN03200; cellulose synthase-interactive protein; Provisional
    PHA03247
    Location:45452
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:457482
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:739779
    Arm; Armadillo/beta-catenin-like repeat
  2. XM_030248379.2XP_030104239.1  catenin delta-2 isoform X2

    Conserved Domains (5) summary
    smart00185
    Location:486526
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:455628
    PLN03200; cellulose synthase-interactive protein; Provisional
    PHA03247
    Location:45452
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:457482
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:739779
    Arm; Armadillo/beta-catenin-like repeat
  3. XM_030248378.2XP_030104238.1  catenin delta-2 isoform X1

    Conserved Domains (5) summary
    smart00185
    Location:486526
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:455628
    PLN03200; cellulose synthase-interactive protein; Provisional
    PHA03247
    Location:45452
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:457482
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:739779
    Arm; Armadillo/beta-catenin-like repeat
  4. XM_030248380.2XP_030104240.1  catenin delta-2 isoform X2

    Conserved Domains (5) summary
    smart00185
    Location:486526
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:455628
    PLN03200; cellulose synthase-interactive protein; Provisional
    PHA03247
    Location:45452
    PHA03247; large tegument protein UL36; Provisional
    sd00043
    Location:457482
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:739779
    Arm; Armadillo/beta-catenin-like repeat