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Nppc natriuretic peptide type C [ Mus musculus (house mouse) ]

Gene ID: 18159, updated on 5-Jan-2023

Summary

Official Symbol
Nppcprovided by MGI
Official Full Name
natriuretic peptide type Cprovided by MGI
Primary source
MGI:MGI:97369
See related
Ensembl:ENSMUSG00000026241 AllianceGenome:MGI:97369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CNP; lbab
Summary
This gene encodes a member of the natriuretic peptide family. Natriuretic peptides are involved in the control of blood pressure, extracellular fluid volume and electrolyte homeostasis. The encoded protein also plays a role in sensory neuron bifurcation, and is a critical regulator of endochondral bone growth. The encoded protein is a ligand for the natriuretic peptide receptor B, and is synthesized as a preprohormone which is cleaved to produce a mature peptide. Mutations in this gene are associated with dwarfism resulting from impaired endochondral ossification. [provided by RefSeq, Apr 2011]
Expression
Biased expression in ovary adult (RPKM 20.5), cerebellum adult (RPKM 4.7) and 7 other tissues See more
Orthologs
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Genomic context

See Nppc in Genome Data Viewer
Location:
1 C5; 1 43.98 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86594015..86598295, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86666293..86670573, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6D, cGMP-specific, rod, delta Neighboring gene COP9 signalosome subunit 7B Neighboring gene predicted gene, 41908 Neighboring gene DIS3 like 3'-5' exoribonuclease 2 Neighboring gene ribosomal protein L6 pseudogene Neighboring gene predicted gene, 41909

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC130574

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables neuropeptide hormone activity TAS
Traceable Author Statement
more info
PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within animal organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in c-di-GMP signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of cGMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glycoprotein IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cumulus cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gastric emptying IDA
Inferred from Direct Assay
more info
PubMed 
involved_in growth plate cartilage chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in growth plate cartilage chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle process involved in oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organismal locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of oocyte maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in oocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of uterine smooth muscle relaxation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor guanylyl cyclase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to decreased oxygen levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxygen-glucose deprivation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-type natriuretic peptide
Names
natriuretic peptide precursor C
natriuretic peptide precursor type C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010933.5NP_035063.1  C-type natriuretic peptide preproprotein

    See identical proteins and their annotated locations for NP_035063.1

    Status: REVIEWED

    Source sequence(s)
    AC158132, AK036176, BY718381
    Consensus CDS
    CCDS15123.1
    UniProtKB/Swiss-Prot
    Q61839
    UniProtKB/TrEMBL
    A0A8C6GCK3, Q544K5
    Related
    ENSMUSP00000027449.5, ENSMUST00000027449.6
    Conserved Domains (1) summary
    pfam00212
    Location:96126
    ANP; Atrial natriuretic peptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    86594015..86598295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)