nlg-1 Carboxylesterase type B domain-containing protein;Neuroligin-1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Gene symbol: nlg-1
Gene description: Carboxylesterase type B domain-containing protein;Neuroligin-1
Primary source: WormBase:WBGene00006412
Locus tag: CELE_C40C9.5
See related: AllianceGenome:WB:WBGene00006412
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable neurexin family protein binding activity and signaling receptor activity. Involved in gamma-aminobutyric acid receptor clustering and negative regulation of neurotransmitter secretion. Located in axon; dendrite; and synapse. Is expressed in body wall musculature; diagonal muscle; head; nervous system; and tail. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to several human genes including NLGN1 (neuroligin 1) and NLGN4X (neuroligin 4 X-linked). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

Location:: chromosome: X

Exon count:: 16

Sequence:: Chromosome: X; NC_003284.9 (13625373..13631172, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Ig-like domain of Punctin/MADD-4 is the primary determinant for interaction with the ectodomain of neuroligin NLG-1.
Title: The Ig-like domain of Punctin/MADD-4 is the primary determinant for interaction with the ectodomain of neuroligin NLG-1.
The authors show that a C elegans mutant in the single gene orthologous to human neuroligins, nlg-1, is defective in food-induced pumping. This was not due to an inability to sense food, as nlg-1 mutants were not defective in chemotaxis towards bacteria. In addition, we found that neuroligin is widely expressed in the nervous system.
Title: Neuroligin tuning of pharyngeal pumping reveals extrapharyngeal modulation of feeding in Caenorhabditis elegans.
Loss of nlg-1 suppresses the hpo-30 mutant phenotype.NLG-1 functions downstream of HPO-30 to maintain the LAChR-dependent functions at the neuromuscular junction.Elevated NLG-1 levels result in decreased LAChRs at the NMJ.
Title: The Claudin-like Protein HPO-30 Is Required to Maintain LAChRs at the C. elegans Neuromuscular Junction.
Neuroligin mutants are defective in a subset of sensory behaviors and sensory processing, and are hypersensitive to oxidative stress and mercury compounds.[Neuroligin-1]
Title: Neuroligin-deficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicity.
The results highlight a developmental regulation of C. elegans nlg-1 that could play a key role in the assembly of synaptic protein complexes during the early stages of nervous system development.
Title: Analysis of splice variants for the C. elegans orthologue of human neuroligin reveals a developmentally regulated transcript.
Neuroligin is involved in modulating the action of dopamine and serotonin in the nematode and suggest that the functional mechanism underpinning both methylphenidate and fluoxetine in C. elegans might be comparable to that in humans.
Title: Neuroligin modulates the locomotory dopaminergic and serotonergic neuronal pathways of C. elegans.
our results suggest that SKN-1 activation in the nervous system can confer protection to organisms in response to stress by directly regulating nlg-1/neuroligin expression.
Title: Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress.
study found neurexin (NRX-1) and neuroligin (NLG-1) mediated a retrograde synaptic signal that inhibited neurotransmitter release at neuromuscular junctions
Title: Neurexin and neuroligin mediate retrograde synaptic inhibition in C. elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

C40C9.5 (e-PCR)
- UniSTS:312518

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables neurexin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid receptor clustering	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gamma-aminobutyric acid receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Carboxylesterase type B domain-containing protein;Neuroligin-1

NP_001257225.1

Confirmed by transcript evidence

NP_001257226.1

Partially confirmed by transcript evidence

NP_001300305.1

Partially confirmed by transcript evidence

NP_001300306.1

Partially confirmed by transcript evidence

NP_001300335.1

Confirmed by transcript evidence

NP_001300336.1

Confirmed by transcript evidence

NP_001359729.1

Partially confirmed by transcript evidence

NP_510283.1

Confirmed by transcript evidence

NP_872254.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13625373..13631172 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_182454.4 → NP_872254.1 Neuroligin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_872254.1

Status: REVIEWED

UniProtKB/TrEMBL

C1KGB4

Conserved Domains (1) summary

pfam00135
Location:23 → 592

COesterase; Carboxylesterase family
NM_077882.6 → NP_510283.1 Neuroligin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510283.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8I0R2, Q9XTG1

UniProtKB/TrEMBL

C1KGB4

Conserved Domains (1) summary

pfam00135
Location:23 → 592

COesterase; Carboxylesterase family
NM_001270296.3 → NP_001257225.1 Carboxylesterase type B domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257225.1

Status: REVIEWED

UniProtKB/TrEMBL

C1KGB4, G5ECG6

Conserved Domains (1) summary

pfam00135
Location:22 → 592

COesterase; Carboxylesterase family
NM_001313376.3 → NP_001300305.1 Carboxylesterase type B domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AT61, C1KGB4

Conserved Domains (1) summary

pfam00135
Location:22 → 595

COesterase; Carboxylesterase family
NM_001313377.3 → NP_001300306.1 Carboxylesterase type B domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AVG1, C1KGB4

Conserved Domains (1) summary

pfam00135
Location:22 → 595

COesterase; Carboxylesterase family
NM_001270297.3 → NP_001257226.1 Carboxylesterase type B domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257226.1

Status: REVIEWED

UniProtKB/TrEMBL

C1KGB4, G5EED7

Conserved Domains (1) summary

pfam00135
Location:22 → 595

COesterase; Carboxylesterase family
NM_001313406.3 → NP_001300335.1 Carboxylesterase type B domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AT91

Conserved Domains (1) summary

cl21494
Location:1 → 219

Abhydrolase; alpha/beta hydrolases
NM_001313407.3 → NP_001300336.1 Carboxylesterase type B domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AVK6

Conserved Domains (1) summary

cl21494
Location:1 → 219

Abhydrolase; alpha/beta hydrolases
NM_001373559.4 → NP_001359729.1 Carboxylesterase type B domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

C1KGB4, G5EFY3

Conserved Domains (1) summary

pfam00135
Location:22 → 595

COesterase; Carboxylesterase family