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alh-13 Glutamate 5-kinase [ Caenorhabditis elegans ]

Gene ID: 181417, updated on 22-Sep-2022

Summary

Gene symbol
alh-13
Gene description
Glutamate 5-kinase
Primary source
WormBase:WBGene00011938
Locus tag
CELE_T22H6.2
See related
AllianceGenome:WB:WBGene00011938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutamate-5-semialdehyde dehydrogenase activity. Predicted to be involved in L-proline biosynthetic process and phosphorylation. Located in mitochondrion. Is expressed in intestine. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See alh-13 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (12782394..12787147)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nuclear Hormone Receptor family Neighboring gene Choline/EthanolaminePhosphoTransferase Neighboring gene Interleukin cytokine-related protein 17.1 Neighboring gene Seven TM Receptor Neighboring gene Seven TM Receptor

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the alh-13 gene: The alh-13 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables glutamate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables glutamate-5-semialdehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutamate-5-semialdehyde dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Glutamate 5-kinase
NP_510132.2
  • Confirmed by transcript evidence
NP_510133.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    12782394..12787147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077731.7NP_510132.2  Glutamate 5-kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510132.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54889, Q9BI69
    Conserved Domains (3) summary
    TIGR01092
    Location:75782
    P5CS; delta l-pyrroline-5-carboxylate synthetase
    cd07079
    Location:357763
    ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
    cd04256
    Location:74346
    AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...
  2. NM_077732.9NP_510133.2  Glutamate 5-kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510133.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54889
    Conserved Domains (3) summary
    TIGR01092
    Location:73780
    P5CS; delta l-pyrroline-5-carboxylate synthetase
    cd07079
    Location:355761
    ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19
    cd04256
    Location:72344
    AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...