atf-6 Transcription factor atf-6 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atf-6
Official Full Name: Transcription factor atf-6 homolog
Primary source: WormBase:WBGene00000222
Locus tag: CELE_F45E6.2
See related: AllianceGenome:WB:WBGene00000222
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including ATF6-mediated unfolded protein response; determination of adult lifespan; and endoplasmic reticulum calcium ion homeostasis. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in nucleus. Is expressed in several structures, including intestine; muscle cell; pharyngeal gland cell; rectum; and vulva. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6) and ATF6B (activating transcription factor 6 beta). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

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See atf-6 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (12480948..12484904)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that miR-124 regulated the expression of atf-6 via binding to its 3' untranslated regions (3'UTR), which contributes to Astragalus polysaccharide (APS)-induced lifespan extension.
Title: miR-124/ATF-6, a novel lifespan extension pathway of Astragalus polysaccharide in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F45E6.2 (e-PCR)
- UniSTS:311234

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATF6-mediated unfolded protein response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to topologically incorrect protein	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription factor atf-6 homolog

NP_510094.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12480948..12484904

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077693.7 → NP_510094.1 Transcription factor atf-6 homolog

See identical proteins and their annotated locations for NP_510094.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20435

Conserved Domains (1) summary

cd14686
Location:250 → 300

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain