ftt-2 14-3-3-like protein 2 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: ftt-2
Gene description: 14-3-3-like protein 2
Primary source: WormBase:WBGene00001502
Locus tag: CELE_F52D10.3
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

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See ftt-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (11604053..11605380, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

FTT-2 binds to DAF-16 in C. elegans and regulates DAF-16 by sequestering it in the cytoplasm
Title: The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans.
results suggest that C. elegans 14-3-3 proteins, par-5 and FTT-2 can regulate longevity by cooperating with both SIR-2.1 and DAF-16/FOXO
Title: C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.
C. elegans 14-3-3 protein is identified as a SIR-2.1 binding partner; required for the life-span extension conferred by extra copies of sir-2.1.
Title: C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Aging, organism-specific biosystem (from WikiPathways)
Aging, organism-specific biosystemAging in C. elegans involves measurable declines in morphology, reproduction, and behavior. Understanding the cellular and molecular processes leading to senescence in this nematode began in the ear...
Dauer formation, organism-specific biosystem (from WikiPathways)
Dauer formation, organism-specific biosystemFrom wormbook: In response to harsh environmental conditions, C. elegans larvae undergo dauer arrest at the second molt. The past decade has yielded many insights into the signaling pathways and the ...
Longevity regulating pathway - worm, organism-specific biosystem (from KEGG)
Longevity regulating pathway - worm, organism-specific biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
Longevity regulating pathway - worm, conserved biosystem (from KEGG)
Longevity regulating pathway - worm, conserved biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F52D10.3 (e-PCR)
- UniSTS:319382

Homology

Homologs of the ftt-2 gene: The ftt-2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IEA Inferred from Electronic Annotation more info
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cytoplasmic sequestering of protein	IMP Inferred from Mutant Phenotype more info	PubMed
dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 14-3-3-like protein 2

NP_001337315.1

Confirmed by transcript evidence

NP_509938.2

Confirmed by transcript evidence

NP_509939.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11604053..11605380 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001350351.1 → NP_001337315.1 14-3-3-like protein 2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl02098
Location:4 → 233

14-3-3; 14-3-3 domain
NM_077538.4 → NP_509939.1 14-3-3-like protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509939.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20655

UniProtKB/TrEMBL

W6E8Z9

Conserved Domains (1) summary

cl02098
Location:4 → 233

14-3-3; 14-3-3 domain
NM_077537.5 → NP_509938.2 14-3-3-like protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509938.2

Status: REVIEWED

UniProtKB/TrEMBL

Q95ZT1

Conserved Domains (1) summary

cl02098
Location:4 → 196

14-3-3; 14-3-3 domain