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vhl-1 von Hippel-Lindau tumor suppressor homolog [ Caenorhabditis elegans ]

Gene ID: 181321, updated on 8-Jul-2018
Gene symbol
vhl-1
Gene description
von Hippel-Lindau tumor suppressor homolog
Primary source
WormBase:WBGene00006922
Locus tag
CELE_F08G12.4
Gene type
protein coding
RNA name
von Hippel-Lindau tumor suppressor homolog
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
See vhl-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
3
Sequence:
Chromosome: X; NC_003284.9 (11307369..11308161)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • ECV complex, organism-specific biosystem (from KEGG)
    ECV complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
  • ECV complex, conserved biosystem (from KEGG)
    ECV complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
  • Longevity regulating pathway - worm, organism-specific biosystem (from KEGG)
    Longevity regulating pathway - worm, organism-specific biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
  • Longevity regulating pathway - worm, conserved biosystem (from KEGG)
    Longevity regulating pathway - worm, conserved biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Cul2-RING ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 
VCB complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
von Hippel-Lindau tumor suppressor homolog
NP_509889.1
  • Confirmed by transcript evidence

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11307369..11308161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077488.3NP_509889.1  von Hippel-Lindau tumor suppressor homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509889.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19213
    Conserved Domains (1) summary
    cd05468
    Location:19157
    pVHL; von Hippel-Landau (pVHL) tumor suppressor protein
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