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Notch3 notch 3 [ Mus musculus (house mouse) ]

Gene ID: 18131, updated on 12-Nov-2019

Summary

Official Symbol
Notch3provided by MGI
Official Full Name
notch 3provided by MGI
Primary source
MGI:MGI:99460
See related
Ensembl:ENSMUSG00000038146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N3; hpbk; AW229011
Expression
Broad expression in lung adult (RPKM 45.0), mammary gland adult (RPKM 29.4) and 20 other tissues See more
Orthologs

Genomic context

See Notch3 in Genome Data Viewer
Location:
17 B1; 17 17.37 cM
Exon count:
34
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32120820..32166896, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (32257838..32303797, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene pyridoxal (pyridoxine, vitamin B6) kinase, pseudogene Neighboring gene predicted gene, 30729 Neighboring gene predicted gene, 38585 Neighboring gene predicted gene, 41568 Neighboring gene VISTA enhancer mm1733 Neighboring gene epoxide hydrolase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch signaling pathway IC
Inferred by Curator
more info
PubMed 
Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
glomerular capillary formation IEP
Inferred from Expression Pattern
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
neurogenic locus notch homolog protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008716.3NP_032742.1  neurogenic locus notch homolog protein 3 precursor

    See identical proteins and their annotated locations for NP_032742.1

    Status: VALIDATED

    Source sequence(s)
    CT033755, CT033797
    Consensus CDS
    CCDS28614.1
    UniProtKB/Swiss-Prot
    Q61982
    Related
    ENSMUSP00000085016.3, ENSMUST00000087723.4
    Conserved Domains (12) summary
    smart00004
    Location:14221459
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:17781894
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:159196
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00204
    Location:18671993
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00066
    Location:14751501
    Notch; LNR domain
    pfam06816
    Location:15091558
    NOD; NOTCH protein
    pfam07684
    Location:15791638
    NODP; NOTCH protein
    pfam11936
    Location:22122274
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:19112003
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:18591914
    Ank_5; Ankyrin repeats (many copies)
    pfam15822
    Location:20522298
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    sd00045
    Location:19061937
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p6 C57BL/6J

    Range
    32120820..32166896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317293.1XP_017172782.1  neurogenic locus notch homolog protein 3 isoform X1

  2. XM_030249555.1XP_030105415.1  neurogenic locus notch homolog protein 3 isoform X2

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