DRD2 dopamine receptor D2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DRD2provided by HGNC
Official Full Name: dopamine receptor D2provided by HGNC
Primary source: HGNC:HGNC:3023
See related: Ensembl:ENSG00000149295 MIM:126450; Vega:OTTHUMG00000167717
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: D2R; D2DR
Summary: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
Annotation information: Note: A frequently studied SNP, known as TaqI DRD2 (rs1800497), was originally associated with the DRD2 gene (GeneID 1813) but was later found to be located within exon 8 of the adjacent gene, ANKK1 (GeneID 255239). The location of rs1800497 is not always specified within publications. Publications may be associated with either locus or with both loci in order to point out the relationship of rs1800497 to both loci. [13 Feb 2013]
Expression: Biased expression in adrenal (RPKM 4.1), endometrium (RPKM 0.7) and 3 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 11q23.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	11	NC_000011.10 (113409595..113475279, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (113280317..113346413, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

crystal structure of DRD2 in complex with the widely prescribed atypical antipsychotic drug risperidone
Title: Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.
childhood urbanicity and variation in dopamine genes COMT, DRD1 and DRD2 alters adult prefrontal function as measured by fMRI
Title: Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI).
analysis of molecular dynamics simulations with a cumulative length of ~77 mus of D2R and D3R wild-type and their E2.65A mutants bound to SB269652
Title: The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.
In schizophrenia patients, presence of DRD2 Taq 1 D2D2 and 5-HT2A C516T CT genotypes in patients were more likely to be associated with non-response to risperidone.
Title: Identification of genetic correlates of response to Risperidone: Findings of a multicentric schizophrenia study from India.
These results led us to hypothesize the existence of functional D2-sigma1R complexes on the rat striatal DA and glutamate nerve terminals and functional D2-sigma1R-DA transporter complexes on the striatal DA terminals.
Title: Cocaine modulates allosteric D<sub>2</sub>-σ<sub>1</sub> receptor-receptor interactions on dopamine and glutamate nerve terminals from rat striatum.
Current smokers showed lower ventral striatum levels of dopamine D2 receptors compared to non-smokers.
Title: Striatal Dopamine D2/D3 Receptor Availability Varies Across Smoking Status.
The glioma-initiating cells self-renewal function regulated by PRRX1 is mediated by dopamine D2 receptor (DRD2). PRRX1 directly binds to the DRD2 promoter and transactivates its expression in glioma-initiating cells.
Title: Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells.
ONC201 is a selective DRD2 antagonist that is well tolerated, achieves micromolar plasma concentrations, and is biologically active in advanced cancer patients when orally administered at 625 mg every 3 weeks
Title: First-in-Human Clinical Trial of Oral ONC201 in Patients with Refractory Solid Tumors.
DRD2 variation is associated with fiber tract integrity between basal ganglia and frontal cortices.
Title: Variation on the dopamine D2 receptor gene (DRD2) is associated with basal ganglia-to-frontal structural connectivity.
The G allele of rs4654327 (OPRD1), DRD2 haplotype block CCGCCGTT (rs6277-rs1076560-rs2283265-rs2734833-rs2075652-rs1079596-rs4436578-rs11214607), and OPRD1 haplotypes TACG (rs6669447-rs2236857-rs508448-rs4654327), CG (rs508448-rs4654327), and TG (rs6669447-rs4654327) were significantly associated with heroin dependence phenotype.
Title: Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese.

Submit: New GeneRIF Correction See all GeneRIFs (792)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Myoclonic dystonia MedGen: C1834570 OMIM: 159900 GeneReviews: Myoclonus-Dystonia	Compare labs

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association with select biomarker traits in the Framingham Heart Study. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Alcoholism, organism-specific biosystem (from KEGG)
Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
Alcoholism, conserved biosystem (from KEGG)
Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
Cocaine addiction, organism-specific biosystem (from KEGG)
Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
Cocaine addiction, conserved biosystem (from KEGG)
Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
Common Pathways Underlying Drug Addiction, organism-specific biosystem (from WikiPathways)
Common Pathways Underlying Drug Addiction, organism-specific biosystemThe pathway was modeled after Figure 2 in Li, et al. 2008 and is based on the common pathways identified in their study as well as protein interaction data. Specifically, glutamate and dopamine neuro...
Dopamine receptors, organism-specific biosystem (from REACTOME)
Dopamine receptors, organism-specific biosystemDopamine receptors play vital roles in processes such as the control of learning, motivation, fine motor control and modulation of neuroendocrine signaling (Giralt JA and Greengard P, 2004). Abnormal...
Dopaminergic synapse, organism-specific biosystem (from KEGG)
Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Dopaminergic synapse, conserved biosystem (from KEGG)
Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
Gap junction, organism-specific biosystem (from KEGG)
Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gap junction, conserved biosystem (from KEGG)
Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
Monoamine GPCRs, organism-specific biosystem
Monoamine GPCRs
Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
Neuroactive ligand-receptor interaction, organism-specific biosystem
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
Neuroactive ligand-receptor interaction, conserved biosystem
Neuroactive ligand-receptor interaction
Nicotine Activity on Dopaminergic Neurons, organism-specific biosystem (from WikiPathways)
Nicotine Activity on Dopaminergic Neurons, organism-specific biosystemNicotine is an alkaloid found in tobacco plants. It is a substance that acts as a stimulant in humans and is one of the main factors responsible for tobacco dependence. When nicotine enters the body,...
Parkinson's disease, organism-specific biosystem (from KEGG)
Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
Rap1 signaling pathway, organism-specific biosystem (from KEGG)
Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
Rap1 signaling pathway, conserved biosystem (from KEGG)
Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
cAMP signaling pathway, organism-specific biosystem (from KEGG)
cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
cAMP signaling pathway, conserved biosystem (from KEGG)
cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC31507 (e-PCR)
- UniSTS:56642

MARC_13871-13872:1007494510:1 (e-PCR)
- UniSTS:267588

DRD2 (e-PCR), detects polymorphism
- UniSTS:26442

DRD2 (e-PCR), detects polymorphism
- UniSTS:262987

RH11104 (e-PCR)
- UniSTS:49077

GDB:196340 (e-PCR)
- UniSTS:155832

PMC311033P6 (e-PCR)
- UniSTS:272844

DRD2 (e-PCR), detects polymorphism
- UniSTS:266487

GDB:182528 (e-PCR)
- UniSTS:155387

G10651 (e-PCR)
- UniSTS:60667

SHGC-148803 (e-PCR)
- UniSTS:173055

Homology

Homologs of the DRD2 gene: The DRD2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog.
Orthologs from Annotation Pipeline: 238 organisms have orthologs with human gene DRD2
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA Inferred from Direct Assay more info	PubMed
drug binding	IDA Inferred from Direct Assay more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
ionotropic glutamate receptor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein coupled receptor internalization	IEA Inferred from Electronic Annotation more info
G-protein coupled receptor signaling pathway	TAS Traceable Author Statement more info
Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
activation of protein kinase activity	IEA Inferred from Electronic Annotation more info
adenohypophysis development	ISS Inferred from Sequence or Structural Similarity more info
adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
adult walking behavior	ISS Inferred from Sequence or Structural Similarity more info
arachidonic acid secretion	IDA Inferred from Direct Assay more info	PubMed
associative learning	ISS Inferred from Sequence or Structural Similarity more info
auditory behavior	IEA Inferred from Electronic Annotation more info
autophagy	IEA Inferred from Electronic Annotation more info
axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
behavioral response to cocaine	ISS Inferred from Sequence or Structural Similarity more info
behavioral response to ethanol	ISS Inferred from Sequence or Structural Similarity more info
branching morphogenesis of a nerve	ISS Inferred from Sequence or Structural Similarity more info
cerebral cortex GABAergic interneuron migration	ISS Inferred from Sequence or Structural Similarity more info
circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
dopamine metabolic process	IC Inferred by Curator more info	PubMed
drinking behavior	IEA Inferred from Electronic Annotation more info
excitatory postsynaptic potential	NAS Non-traceable Author Statement more info	PubMed
grooming behavior	IEA Inferred from Electronic Annotation more info
locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
long-term memory	IEA Inferred from Electronic Annotation more info
negative regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell death	IEA Inferred from Electronic Annotation more info
negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of circadian sleep/wake cycle, sleep	IEA Inferred from Electronic Annotation more info
negative regulation of dopamine receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
negative regulation of innate immune response	IEA Inferred from Electronic Annotation more info
negative regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
negative regulation of protein kinase B signaling	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of protein kinase B signaling	NAS Non-traceable Author Statement more info	PubMed
negative regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
negative regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
negative regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
neurological system process involved in regulation of systemic arterial blood pressure	ISS Inferred from Sequence or Structural Similarity more info
neuron-neuron synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
orbitofrontal cortex development	IEA Inferred from Electronic Annotation more info
peristalsis	ISS Inferred from Sequence or Structural Similarity more info
phospholipase C-activating dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
pigmentation	IEA Inferred from Electronic Annotation more info
positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
positive regulation of G-protein coupled receptor protein signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of dopamine uptake involved in synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of glial cell-derived neurotrophic factor secretion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of growth hormone secretion	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
positive regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
positive regulation of neuroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of receptor internalization	IEA Inferred from Electronic Annotation more info
positive regulation of renal sodium excretion	IEA Inferred from Electronic Annotation more info
positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
positive regulation of urine volume	IEA Inferred from Electronic Annotation more info
postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
prepulse inhibition	ISS Inferred from Sequence or Structural Similarity more info
protein localization	ISS Inferred from Sequence or Structural Similarity more info
regulation of dopamine uptake involved in synaptic transmission	IC Inferred by Curator more info	PubMed
regulation of heart rate	ISS Inferred from Sequence or Structural Similarity more info
regulation of locomotion involved in locomotory behavior	IEA Inferred from Electronic Annotation more info
regulation of long-term neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
regulation of phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
regulation of potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
regulation of synapse structural plasticity	IEA Inferred from Electronic Annotation more info
regulation of synaptic transmission, GABAergic	ISS Inferred from Sequence or Structural Similarity more info
regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
response to amphetamine	ISS Inferred from Sequence or Structural Similarity more info
response to axon injury	IEA Inferred from Electronic Annotation more info
response to cocaine	ISS Inferred from Sequence or Structural Similarity more info
response to drug	ISS Inferred from Sequence or Structural Similarity more info
response to histamine	IDA Inferred from Direct Assay more info	PubMed
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to inactivity	IEA Inferred from Electronic Annotation more info
response to iron ion	IEA Inferred from Electronic Annotation more info
response to light stimulus	ISS Inferred from Sequence or Structural Similarity more info
response to morphine	ISS Inferred from Sequence or Structural Similarity more info
response to nicotine	IEA Inferred from Electronic Annotation more info
sensory perception of smell	ISS Inferred from Sequence or Structural Similarity more info
striatum development	IEA Inferred from Electronic Annotation more info
synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
temperature homeostasis	ISS Inferred from Sequence or Structural Similarity more info
visual learning	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
acrosomal vesicle	IEA Inferred from Electronic Annotation more info
axon	ISS Inferred from Sequence or Structural Similarity more info
axon terminus	IEA Inferred from Electronic Annotation more info
ciliary membrane	IDA Inferred from Direct Assay more info	PubMed
dendrite	ISS Inferred from Sequence or Structural Similarity more info
dendritic spine	IEA Inferred from Electronic Annotation more info
dopaminergic synapse	IEA Inferred from Electronic Annotation more info
endocytic vesicle	IEA Inferred from Electronic Annotation more info
glutamatergic synapse	IEA Inferred from Electronic Annotation more info
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
integral component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
integral component of postsynaptic membrane	IEA Inferred from Electronic Annotation more info
integral component of presynaptic membrane	IEA Inferred from Electronic Annotation more info
lateral plasma membrane	IEA Inferred from Electronic Annotation more info
non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
perikaryon	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
postsynaptic density	IEA Inferred from Electronic Annotation more info
sperm flagellum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: D(2) dopamine receptor

Names: dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008841.1 RefSeqGene

Range

5001..70685

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000795.3 → NP_000786.1 D(2) dopamine receptor isoform long

See identical proteins and their annotated locations for NP_000786.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (long).

Source sequence(s)

BC021195, BF437994, DA693976, X51362

Consensus CDS

CCDS8361.1

UniProtKB/Swiss-Prot

P14416

UniProtKB/TrEMBL

A0A024R3C5

Related

ENSP00000354859.3, OTTHUMP00000236613, ENST00000362072.7, OTTHUMT00000395834

Conserved Domains (1) summary

cd15309
Location:35 → 437

7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_016574.3 → NP_057658.2 D(2) dopamine receptor isoform short

See identical proteins and their annotated locations for NP_057658.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal exon, as compared to variant 1, but maintains the same reading frame. It encodes an isoform (short), which is 29 aa shorter than isoform long.

Source sequence(s)

BC021195, BF437994, DA693976, S69899, X51362

Consensus CDS

CCDS8362.1

UniProtKB/Swiss-Prot

P14416

UniProtKB/TrEMBL

A0A024R3I6

Related

ENSP00000278597.5, OTTHUMP00000236612, ENST00000346454.7, OTTHUMT00000395833

Conserved Domains (1) summary

cd15309
Location:35 → 408

7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p12 Primary Assembly

Range

113409595..113475279 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017017296.2 → XP_016872785.1 D(2) dopamine receptor isoform X1

UniProtKB/Swiss-Prot

P14416

UniProtKB/TrEMBL

A0A024R3C5

Related

ENSP00000442172.1, OTTHUMP00000236615, ENST00000542968.5

Conserved Domains (1) summary

cd15309
Location:35 → 437

7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors