DRD2 dopamine receptor D2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DRD2provided by HGNC
Official Full Name: dopamine receptor D2provided by HGNC
Primary source: HGNC:HGNC:3023
See related: Ensembl:ENSG00000149295 MIM:126450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: D2R; D2DR
Summary: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
Annotation information: Note: A frequently studied SNP, known as TaqI DRD2 (rs1800497), was originally associated with the DRD2 gene (GeneID 1813) but was later found to be located within exon 8 of the adjacent gene, ANKK1 (GeneID 255239). The location of rs1800497 is not always specified within publications. Publications may be associated with either locus or with both loci in order to point out the relationship of rs1800497 to both loci. [13 Feb 2013]
Expression: Biased expression in adrenal (RPKM 4.1), endometrium (RPKM 0.7) and 3 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 11q23.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	11	NC_000011.10 (113409595..113475279, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (113280317..113346413, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

results reveal that the D2R can directly recruit GRK2 without G protein activation and that this mechanism may have relevance to achieving betaarr-biased signaling
Title: The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.
The results from this study indicate that dopamine D2 receptor polymorphisms together with body mass index are important determinants to include in research that tests prediction error response of the brain.
Title: Dopamine D2 -141C Ins/Del and Taq1A polymorphisms, body mass index, and prediction error brain response.
DRD2 variant associated with task-specific anomaly in the directional flow of information or disconnection between the amygdala and the prefrontal cortex during emotional processing in persons with schizophrenia ant their siblings.
Title: Familial Risk and a Genome-Wide Supported DRD2 Variant for Schizophrenia Predict Lateral Prefrontal-Amygdala Effective Connectivity During Emotion Processing.
findings suggest that DRD2 levels might affect the progression of urothelial cell carcinoma (UCC), and the polymorphisms rs6277, rs1800497, and rs1799732 of DRD2 are probably associated with the susceptibility and clinicopathologic development of UCC in a Taiwanese population.
Title: Dopamine receptor D2 genetic variations is associated with the risk and clinicopathological variables of urothelial cell carcinoma in a Taiwanese population.
In the overall participants, the DRD2 Taq 1A polymorphism itself was not related to IQ scores in children who had a high level of urine fluoride. In the CC/CT subgroup, urine fluoride levels and IQ scores in children were unrelated. Among the participants carrying the TT genotype, there was a strong and robust negative linear relationship between log-urine fluoride and IQ scores.
Title: Dopamine receptor D2 gene polymorphism, urine fluoride, and intelligence impairment of children in China: A school-based cross-sectional study.
this study demonstrated a protective role of D2R in neutrophil-endothelial cell adhesion induced by bradykinin, especially in cytokine-stimulated endothelial cells.
Title: Bradykinin B2 receptor and dopamine D2 receptor cooperatively contribute to the regulation of neutrophil adhesion to endothelial cells.
DRD2 Ins/Ins (prevalence ratio (PR)=2.374, 95% confidence interval (CI): 1.105-5.100; P=0.027) and DRD3 Ser/Ser genotypes (PR=1.677, 95% CI 1.077-2.611; P=0.022) were independent and predictors of gastrointestinal symptoms associated with levodopa therapy.
Title: Association between DRD2 and DRD3 gene polymorphisms and gastrointestinal symptoms induced by levodopa therapy in Parkinson's disease.
genetically determined differences in DAT1 and DRD2 expression modulate functional consequences of sleep deprivation.
Title: Functional Polymorphisms in Dopaminergic Genes Modulate Neurobehavioral and Neurophysiological Consequences of Sleep Deprivation.
Study represents the first comprehensive investigation of the association between both striatal and extrastriatal D2/D3 receptor binding potential with executive function and verbal learning in medication-naive (5 drug-free) patients with schizophrenia; demonstrates that lower fallypride binding potential in patients with schizophrenia may be associated with better performance.
Title: D2/D3 dopamine receptor binding with [F-18]fallypride correlates of executive function in medication-naïve patients with schizophrenia.
these results suggest that among schizophrenia patients at the chronic stage, there is a relationship between Del carriers and high-dose pharmacotherapy.
Title: The impacts of dopamine D2 receptor polymorphism and antipsychotic dosage on dopamine supersensitivity psychosis in schizophrenia.

Submit: New GeneRIF Correction See all GeneRIFs (810)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association with select biomarker traits in the Framingham Heart Study. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

Go to the top of the page Help

Alcoholism, organism-specific biosystem (from KEGG)
Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
Alcoholism, conserved biosystem (from KEGG)
Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
Cocaine addiction, organism-specific biosystem (from KEGG)
Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
Cocaine addiction, conserved biosystem (from KEGG)
Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
Common Pathways Underlying Drug Addiction, organism-specific biosystem (from WikiPathways)
Common Pathways Underlying Drug Addiction, organism-specific biosystemThe pathway was modeled after Figure 2 in Li, et al. 2008 and is based on the common pathways identified in their study as well as protein interaction data. Specifically, glutamate and dopamine neuro...
Dopamine receptors, organism-specific biosystem (from REACTOME)
Dopamine receptors, organism-specific biosystemDopamine receptors play vital roles in processes such as the control of learning, motivation, fine motor control and modulation of neuroendocrine signaling (Giralt JA and Greengard P, 2004). Abnormal...
Dopaminergic synapse, organism-specific biosystem (from KEGG)
Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Dopaminergic synapse, conserved biosystem (from KEGG)
Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
Gap junction, organism-specific biosystem (from KEGG)
Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gap junction, conserved biosystem (from KEGG)
Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
Monoamine GPCRs, organism-specific biosystem
Monoamine GPCRs
Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
Neuroactive ligand-receptor interaction, organism-specific biosystem
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
Neuroactive ligand-receptor interaction, conserved biosystem
Neuroactive ligand-receptor interaction
Nicotine Activity on Dopaminergic Neurons, organism-specific biosystem (from WikiPathways)
Nicotine Activity on Dopaminergic Neurons, organism-specific biosystemNicotine is an alkaloid found in tobacco plants. It is a substance that acts as a stimulant in humans and is one of the main factors responsible for tobacco dependence. When nicotine enters the body,...
Parkinson's disease, organism-specific biosystem (from KEGG)
Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
Rap1 signaling pathway, organism-specific biosystem (from KEGG)
Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
Rap1 signaling pathway, conserved biosystem (from KEGG)
Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
cAMP signaling pathway, organism-specific biosystem (from KEGG)
cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
cAMP signaling pathway, conserved biosystem (from KEGG)
cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SGC31507 (e-PCR)
- UniSTS:56642

MARC_13871-13872:1007494510:1 (e-PCR)
- UniSTS:267588

DRD2 (e-PCR), detects polymorphism
- UniSTS:26442

DRD2 (e-PCR), detects polymorphism
- UniSTS:262987

RH11104 (e-PCR)
- UniSTS:49077

GDB:196340 (e-PCR)
- UniSTS:155832

PMC311033P6 (e-PCR)
- UniSTS:272844

DRD2 (e-PCR), detects polymorphism
- UniSTS:266487

GDB:182528 (e-PCR)
- UniSTS:155387

G10651 (e-PCR)
- UniSTS:60667

SHGC-148803 (e-PCR)
- UniSTS:173055

Homology

Homologs of the DRD2 gene: The DRD2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog.
Orthologs from Annotation Pipeline: 253 organisms have orthologs with human gene DRD2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
dopamine binding	IEA Inferred from Electronic Annotation more info
dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA Inferred from Direct Assay more info	PubMed
drug binding	IDA Inferred from Direct Assay more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
ionotropic glutamate receptor binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G protein-coupled receptor internalization	IEA Inferred from Electronic Annotation more info
G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
activation of protein kinase activity	IEA Inferred from Electronic Annotation more info
adenohypophysis development	ISS Inferred from Sequence or Structural Similarity more info
adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
adult walking behavior	ISS Inferred from Sequence or Structural Similarity more info
arachidonic acid secretion	IDA Inferred from Direct Assay more info	PubMed
associative learning	ISS Inferred from Sequence or Structural Similarity more info
auditory behavior	IEA Inferred from Electronic Annotation more info
autophagy	IEA Inferred from Electronic Annotation more info
axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
behavioral response to cocaine	ISS Inferred from Sequence or Structural Similarity more info
behavioral response to ethanol	ISS Inferred from Sequence or Structural Similarity more info
branching morphogenesis of a nerve	ISS Inferred from Sequence or Structural Similarity more info
cerebral cortex GABAergic interneuron migration	ISS Inferred from Sequence or Structural Similarity more info
circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
dopamine metabolic process	IC Inferred by Curator more info	PubMed
drinking behavior	IEA Inferred from Electronic Annotation more info
excitatory postsynaptic potential	NAS Non-traceable Author Statement more info	PubMed
grooming behavior	IEA Inferred from Electronic Annotation more info
locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
long-term memory	IEA Inferred from Electronic Annotation more info
negative regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell death	IEA Inferred from Electronic Annotation more info
negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of circadian sleep/wake cycle, sleep	IEA Inferred from Electronic Annotation more info
negative regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
negative regulation of dopamine receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info
negative regulation of innate immune response	IEA Inferred from Electronic Annotation more info
negative regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
negative regulation of protein kinase B signaling	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of protein kinase B signaling	NAS Non-traceable Author Statement more info	PubMed
negative regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
negative regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
negative regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
neurological system process involved in regulation of systemic arterial blood pressure	ISS Inferred from Sequence or Structural Similarity more info
neuron-neuron synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
orbitofrontal cortex development	IEA Inferred from Electronic Annotation more info
peristalsis	ISS Inferred from Sequence or Structural Similarity more info
phospholipase C-activating dopamine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
pigmentation	IEA Inferred from Electronic Annotation more info
positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
positive regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of dopamine uptake involved in synaptic transmission	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of glial cell-derived neurotrophic factor secretion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of growth hormone secretion	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
positive regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
positive regulation of neuroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of receptor internalization	IEA Inferred from Electronic Annotation more info
positive regulation of renal sodium excretion	IEA Inferred from Electronic Annotation more info
positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
positive regulation of urine volume	IEA Inferred from Electronic Annotation more info
postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
prepulse inhibition	ISS Inferred from Sequence or Structural Similarity more info
protein localization	ISS Inferred from Sequence or Structural Similarity more info
regulation of dopamine uptake involved in synaptic transmission	IC Inferred by Curator more info	PubMed
regulation of heart rate	ISS Inferred from Sequence or Structural Similarity more info
regulation of locomotion involved in locomotory behavior	IEA Inferred from Electronic Annotation more info
regulation of long-term neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
regulation of phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
regulation of potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
regulation of synapse structural plasticity	IEA Inferred from Electronic Annotation more info
regulation of synaptic transmission, GABAergic	ISS Inferred from Sequence or Structural Similarity more info
regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
response to amphetamine	ISS Inferred from Sequence or Structural Similarity more info
response to axon injury	IEA Inferred from Electronic Annotation more info
response to cocaine	ISS Inferred from Sequence or Structural Similarity more info
response to drug	ISS Inferred from Sequence or Structural Similarity more info
response to histamine	IDA Inferred from Direct Assay more info	PubMed
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to inactivity	IEA Inferred from Electronic Annotation more info
response to iron ion	IEA Inferred from Electronic Annotation more info
response to light stimulus	ISS Inferred from Sequence or Structural Similarity more info
response to morphine	ISS Inferred from Sequence or Structural Similarity more info
response to nicotine	IEA Inferred from Electronic Annotation more info
sensory perception of smell	ISS Inferred from Sequence or Structural Similarity more info
striatum development	IEA Inferred from Electronic Annotation more info
synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
synaptic transmission, dopaminergic	IEA Inferred from Electronic Annotation more info
temperature homeostasis	ISS Inferred from Sequence or Structural Similarity more info
visual learning	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
acrosomal vesicle	IEA Inferred from Electronic Annotation more info
axon	ISS Inferred from Sequence or Structural Similarity more info
axon terminus	IEA Inferred from Electronic Annotation more info
ciliary membrane	IDA Inferred from Direct Assay more info	PubMed
dendrite	ISS Inferred from Sequence or Structural Similarity more info
dendritic spine	IEA Inferred from Electronic Annotation more info
dopaminergic synapse	IEA Inferred from Electronic Annotation more info
endocytic vesicle	IEA Inferred from Electronic Annotation more info
glutamatergic synapse	IEA Inferred from Electronic Annotation more info
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
integral component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
integral component of postsynaptic membrane	IEA Inferred from Electronic Annotation more info
integral component of presynaptic membrane	IEA Inferred from Electronic Annotation more info
lateral plasma membrane	IEA Inferred from Electronic Annotation more info
non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
perikaryon	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
postsynaptic density	IEA Inferred from Electronic Annotation more info
sperm flagellum	IEA Inferred from Electronic Annotation more info
synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: D(2) dopamine receptor

Names: dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008841.1 RefSeqGene

Range

5001..70685

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000795.4 → NP_000786.1 D(2) dopamine receptor isoform long

See identical proteins and their annotated locations for NP_000786.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (long).

Source sequence(s)

AP002840, BC021195, BF437994, DA693976, X51362

Consensus CDS

CCDS8361.1

UniProtKB/Swiss-Prot

P14416

UniProtKB/TrEMBL

A0A024R3C5

Related

ENSP00000354859.3, ENST00000362072.7

Conserved Domains (1) summary

cd15309
Location:35 → 437

7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_016574.3 → NP_057658.2 D(2) dopamine receptor isoform short

See identical proteins and their annotated locations for NP_057658.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an internal exon, as compared to variant 1, but maintains the same reading frame. It encodes an isoform (short), which is 29 aa shorter than isoform long.

Source sequence(s)

BC021195, BF437994, DA693976, S69899, X51362

Consensus CDS

CCDS8362.1

UniProtKB/Swiss-Prot

P14416

UniProtKB/TrEMBL

A0A024R3I6

Related

ENSP00000278597.5, ENST00000346454.7

Conserved Domains (1) summary

cd15309
Location:35 → 408

7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p12 Primary Assembly

Range

113409595..113475279 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017017296.2 → XP_016872785.1 D(2) dopamine receptor isoform X1

UniProtKB/Swiss-Prot

P14416

UniProtKB/TrEMBL

A0A024R3C5

Related

ENSP00000442172.1, ENST00000542968.5

Conserved Domains (1) summary

cd15309
Location:35 → 437

7tmA_D2_dopamine_R; D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors