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daf-12 Nuclear hormone receptor family member daf-12 [ Caenorhabditis elegans ]

Gene ID: 181263, updated on 28-May-2020

Summary

Gene symbol
daf-12
Gene description
Nuclear hormone receptor family member daf-12
Primary source
WormBase:WBGene00000908
Locus tag
CELE_F11A1.3
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See daf-12 in Genome Data Viewer
Location:
chromosome: X
Exon count:
18
Sequence:
Chromosome: X; NC_003284.9 (10644440..10666875)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Neighboring gene PlsC domain-containing protein Neighboring gene Neighboring gene Neighboring gene Neighboring gene Neighboring gene Neighboring gene Neighboring gene

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
(25S)-Delta(4)-dafachronate binding IDA
Inferred from Direct Assay
more info
PubMed 
(25S)-Delta(7)-dafachronate binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
chemotaxis to cAMP IGI
Inferred from Genetic Interaction
more info
PubMed 
cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dauer larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of chemical stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
heat acclimation IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
male mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dauer larval development IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of development, heterochronic IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to biotin IGI
Inferred from Genetic Interaction
more info
PubMed 
response to inorganic substance IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Nuclear hormone receptor family member daf-12
NP_001024547.1
  • Confirmed by transcript evidence
NP_001041239.1
  • Confirmed by transcript evidence
NP_001366986.1
  • Confirmed by transcript evidence
NP_001366987.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10644440..10666875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029376.6NP_001024547.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024547.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFF5
    Conserved Domains (2) summary
    cd06929
    Location:548733
    NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1
    cd06966
    Location:116209
    NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers
  2. NM_001047774.5NP_001041239.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041239.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFF5
    Conserved Domains (2) summary
    cd06929
    Location:514699
    NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1
    cd06966
    Location:82175
    NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers
  3. NM_001381088.1NP_001366986.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

    Status: REVIEWED

  4. NM_001381089.2NP_001366987.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

    Status: REVIEWED

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