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daf-12 Nuclear hormone receptor family member daf-12 [ Caenorhabditis elegans ]

Gene ID: 181263, updated on 12-Jan-2018
Gene symbol
daf-12
Gene description
Nuclear hormone receptor family member daf-12
Primary source
WormBase:WBGene00000908
Locus tag
CELE_F11A1.3
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Location:
chromosome: X
Exon count:
18
Sequence:
Chromosome: X; NC_003284.9 (10644440..10665481)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA Neighboring gene tRNA

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Dauer formation, organism-specific biosystem (from WikiPathways)
    Dauer formation, organism-specific biosystemFrom wormbook: In response to harsh environmental conditions, C. elegans larvae undergo dauer arrest at the second molt. The past decade has yielded many insights into the signaling pathways and the ...
  • Heterochronic gene regulation of development, organism-specific biosystem (from WikiPathways)
    Heterochronic gene regulation of development, organism-specific biosystem"The heterochronic gene pathway of Caenorhabditis elegans. The heterochronic pathway regulating larval development is shown. The arrows indicate activation; bars indicate repression. Regulatory relat...
  • Longevity regulating pathway - worm, organism-specific biosystem (from KEGG)
    Longevity regulating pathway - worm, organism-specific biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
  • Longevity regulating pathway - worm, conserved biosystem (from KEGG)
    Longevity regulating pathway - worm, conserved biosystemThe nematode Caenorhabditis elegans has proven to be a very useful tool for studying the genetics of longevity due to its simple biology. Over 70 genes have been found to influence lifespan in this w...
  • Metapathway Signal Transduction, organism-specific biosystem (from WikiPathways)
    Metapathway Signal Transduction, organism-specific biosystem
    Metapathway Signal Transduction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
chemotaxis to cAMP IGI
Inferred from Genetic Interaction
more info
PubMed 
dauer entry IEA
Inferred from Electronic Annotation
more info
PubMed 
dauer larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of chemical stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
PubMed 
determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
heat acclimation IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT heat acclimation IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lipid storage IEA
Inferred from Electronic Annotation
more info
PubMed 
male mating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
nematode larval development IEA
Inferred from Electronic Annotation
more info
PubMed 
positive regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dauer larval development IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of development, heterochronic IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to biotin IGI
Inferred from Genetic Interaction
more info
PubMed 
response to inorganic substance IGI
Inferred from Genetic Interaction
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
Nuclear hormone receptor family member daf-12
NP_001024547.1
  • Confirmed by transcript evidence
NP_001024548.1
  • Confirmed by transcript evidence
NP_001024549.1
  • Confirmed by transcript evidence
NP_001041239.1
  • Confirmed by transcript evidence

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10644440..10665481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029376.4NP_001024547.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024547.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFF5
    Conserved Domains (2) summary
    cd06929
    Location:548733
    NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1
    cd06966
    Location:116209
    NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers
  2. NM_001047774.2NP_001041239.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041239.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFF5
    Conserved Domains (2) summary
    cd06929
    Location:514699
    NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1
    cd06966
    Location:82175
    NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers
  3. NM_001029377.3NP_001024548.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024548.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFF5
    Conserved Domains (2) summary
    cd06929
    Location:489674
    NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1
    cd06966
    Location:57150
    NR_DBD_CAR; DNA-binding domain of constitutive androstane receptor (CAR) is composed of two C4-type zinc fingers
  4. NM_001029378.1NP_001024549.1  Nuclear hormone receptor family member daf-12 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024549.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFF5
    Conserved Domains (1) summary
    cd06929
    Location:62247
    NR_LBD_F1; Ligand-binding domain of nuclear receptor family 1
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