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abl-1 Tyrosine-protein kinase abl-1 [ Caenorhabditis elegans ]

Gene ID: 181261, updated on 8-Sep-2019

Summary

Gene symbol
abl-1
Gene description
Tyrosine-protein kinase abl-1
Primary source
WormBase:WBGene00000018
Locus tag
CELE_M79.1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See abl-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Sequence:
Chromosome: X; NC_003284.9 (10605832..10624185, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene WANQVRF-amide Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hypothetical protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage checkpoint IGI
Inferred from Genetic Interaction
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA damage response, signal transduction by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of engulfment of apoptotic cell IGI
Inferred from Genetic Interaction
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Tyrosine-protein kinase abl-1
NP_509777.2
  • Partially confirmed by transcript evidence
NP_509778.2
  • Confirmed by transcript evidence
NP_509779.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10605832..10624185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077377.5NP_509778.2  Tyrosine-protein kinase abl-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509778.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P03949
    Conserved Domains (5) summary
    smart00808
    Location:10911224
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:190283
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:119185
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:304566
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:311562
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_077376.7NP_509777.2  Tyrosine-protein kinase abl-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509777.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P03949
    Conserved Domains (5) summary
    smart00808
    Location:10811214
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:180273
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:109175
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:294556
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:301552
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_077378.3NP_509779.2  Tyrosine-protein kinase abl-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509779.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P03949
    Conserved Domains (5) summary
    smart00808
    Location:10761209
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:175268
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:104170
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:289551
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:296547
    Pkinase_Tyr; Protein tyrosine kinase
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