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sdn-1 Syndecan;putative syndecan [ Caenorhabditis elegans ]

Gene ID: 181259, updated on 3-May-2025
Official Symbol
sdn-1
Official Full Name
Syndecan;putative syndecan
Primary source
WormBase:WBGene00004749
Locus tag
CELE_F57C7.3
See related
AllianceGenome:WB:WBGene00004749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in embryo development; epidermis morphogenesis; and nematode larval development. Located in cell surface. Is expressed in several structures, including ABar; C; neuroblasts; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in cleft lip and cleft palate. Orthologous to several human genes including SDC2 (syndecan 2) and SDC4 (syndecan 4). [provided by Alliance of Genome Resources, May 2025]
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See sdn-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (10589770..10593334, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sodium/hydrogen exchanger Neighboring gene PKD/REJ-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Caenorhabditis elegans syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva. Minniti AN, et al. J Cell Sci, 2004 Oct 1. PMID 15456854
  2. Syndecan promotes axon regeneration by stabilizing growth cone migration. Edwards TJ, et al. Cell Rep, 2014 Jul 10. PMID 25001284, Free PMC Article
  3. The HSPG syndecan is a core organizer of cholinergic synapses. Zhou X, et al. J Cell Biol, 2021 Sep 6. PMID 34213535, Free PMC Article
  4. Coordination of Heparan Sulfate Proteoglycans with Wnt Signaling To Control Cellular Migrations and Positioning in Caenorhabditis elegans. Saied-Santiago K, et al. Genetics, 2017 Aug. PMID 28576860, Free PMC Article
  5. SDN-1/syndecan regulates growth factor signaling in distal tip cell migrations in C. elegans. Schwabiuk M, et al. Dev Biol, 2009 Oct 1. PMID 19631636

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A somatic proteoglycan controls Notch-directed germ cell fate.
    Title: A somatic proteoglycan controls Notch-directed germ cell fate.
  2. The HSPG syndecan is a core organizer of cholinergic synapses.
    Title: The HSPG syndecan is a core organizer of cholinergic synapses.
  3. SDN-1 controls cell migration in nervous system in coordination with Wnt signaling.
    Title: Coordination of Heparan Sulfate Proteoglycans with Wnt Signaling To Control Cellular Migrations and Positioning in Caenorhabditis elegans.
  4. The sdn-1 mutants showed QR descendant AQR anterior migration defects, and weaker QL descendant PQR migration defects.
    Title: SDN-1/Syndecan Acts in Parallel to the Transmembrane Molecule MIG-13 to Promote Anterior Neuroblast Migration.
  5. Syndecan's core protein, not its sugar chains, mediates growth cone stabilization. Syndecan also functions in axon guidance via its sugar chains.
    Title: Syndecan promotes axon regeneration by stabilizing growth cone migration.
  6. SDN-1 is required for precise orientation of the mitotic spindle in response to a Wnt cue in development.
    Title: Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans.
  7. SDN-1 affects UNC-5 function by regulating the proper extracellular distribution of growth factors
    Title: SDN-1/syndecan regulates growth factor signaling in distal tip cell migrations in C. elegans.
  8. distinct heparan sulfate modification patterns on SDN-1 are involved in regulating axon guidance and cell migration in C. elegans
    Title: Syndecan regulates cell migration and axon guidance in C. elegans.
  9. syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva
    Title: Caenorhabditis elegans syndecan (SDN-1) is required for normal egg laying and associates with the nervous system and the vulva.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epidermis morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in epidermis morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Syndecan;putative syndecan
NP_741893.1
  • Confirmed by transcript evidence
NP_741894.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10589770..10593334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171972.7 → NP_741894.1  putative syndecan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741894.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P50605
    Conserved Domains (1) summary
    pfam01034
    Location:227 → 286
    Syndecan; Syndecan domain

  2. NM_171769.7 → NP_741893.1  Syndecan [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741893.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I4H9
    Conserved Domains (1) summary
    pfam01034
    Location:226 → 285
    Syndecan; Syndecan domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50605.1

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