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Nr4a3 nuclear receptor subfamily 4, group A, member 3 [ Mus musculus (house mouse) ]

Gene ID: 18124, updated on 2-Oct-2021

Summary

Official Symbol
Nr4a3provided by MGI
Official Full Name
nuclear receptor subfamily 4, group A, member 3provided by MGI
Primary source
MGI:MGI:1352457
See related
Ensembl:ENSMUSG00000028341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NO; CHN; TEC; CSMF; Nor1; MINOR; NOR-1; AI573420
Summary
This gene encodes a member of the NR4A subfamily of nuclear hormone receptors that bind to DNA and modulate gene expression. The encoded protein has been implicated in T and B lymphocyte apoptosis, and immune cell proliferation. Mice lacking the encoded protein exhibit partial bidirectional circling behavior and inner ear dysfunction. Disruption of this gene in mice also results in defective hippocampal axonal growth and postnatal neuronal cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression
Biased expression in adrenal adult (RPKM 14.5), CNS E18 (RPKM 3.8) and 11 other tissues See more
Orthologs
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Genomic context

See Nr4a3 in Genome Data Viewer
Location:
4; 4 B1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (48045098..48086446)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (48045078..48086447)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (48064120..48096224)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46853 Neighboring gene predicted gene, 52735 Neighboring gene syntaxin 17 Neighboring gene endoplasmic reticulum protein 44 Neighboring gene microRNA 1958

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP response element binding IDA
Inferred from Direct Assay
more info
PubMed 
enables glucocorticoid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to catecholamine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to corticotropin-releasing hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to corticotropin-releasing hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to leptin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in common myeloid progenitor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hydrogen peroxide-induced neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of oxidative stress-induced neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of leukocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mast cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monocyte aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monocyte aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in pyruvate oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within semicircular canal morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vestibular reflex IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear receptor subfamily 4 group A member 3
Names
neural orphan receptor 1
orphan nuclear receptor TEC
translocated in extraskeletal chondrosarcoma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307989.2NP_001294918.1  nuclear receptor subfamily 4 group A member 3 isoform 2

    See identical proteins and their annotated locations for NP_001294918.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL683893
    UniProtKB/Swiss-Prot
    Q9QZB6
    Conserved Domains (1) summary
    cd06969
    Location:291365
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  2. NM_015743.3NP_056558.1  nuclear receptor subfamily 4 group A member 3 isoform 1

    See identical proteins and their annotated locations for NP_056558.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI606940, AL683893, BC038520, BC068150
    Consensus CDS
    CCDS18163.1
    UniProtKB/Swiss-Prot
    Q9QZB6
    Related
    ENSMUSP00000030025.4, ENSMUST00000030025.10
    Conserved Domains (2) summary
    cd06969
    Location:291365
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:397627
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    48045098..48086446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537656.5XP_006537719.1  nuclear receptor subfamily 4 group A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006537719.1

    UniProtKB/Swiss-Prot
    Q9QZB6
    Conserved Domains (2) summary
    cd06969
    Location:291365
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:397627
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. XM_006537657.5XP_006537720.1  nuclear receptor subfamily 4 group A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006537720.1

    UniProtKB/Swiss-Prot
    Q9QZB6
    Conserved Domains (2) summary
    cd06969
    Location:291365
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:397627
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  3. XM_006537658.2XP_006537721.1  nuclear receptor subfamily 4 group A member 3 isoform X1

    See identical proteins and their annotated locations for XP_006537721.1

    UniProtKB/Swiss-Prot
    Q9QZB6
    Related
    ENSMUSP00000121455.2, ENSMUST00000153369.2
    Conserved Domains (2) summary
    cd06969
    Location:291365
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:397627
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  4. XM_030253308.2XP_030109168.1  nuclear receptor subfamily 4 group A member 3 isoform X1

    Conserved Domains (2) summary
    cd06969
    Location:291365
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:397627
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
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