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cysl-1 Cysteine synthase 1 [ Caenorhabditis elegans ]

Gene ID: 181209, updated on 18-Sep-2024

Summary

Official Symbol
cysl-1
Official Full Name
Cysteine synthase 1
Primary source
WormBase:WBGene00007653
Locus tag
CELE_C17G1.7
See related
AllianceGenome:WB:WBGene00007653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cysteine synthase activity and enzyme binding activity. Involved in cysteine biosynthetic process from serine and response to hypoxia. Located in striated muscle dense body. Is expressed in several structures, including body wall musculature; head ganglion; intestine; neurons; and non-striated muscle. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See cysl-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (9952579..9954533, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Zinc metalloproteinase nas-37 Neighboring gene ncRNA Neighboring gene alpha-1,2-Mannosidase Neighboring gene Phosphatidylserine synthase Neighboring gene G-protein coupled receptors family 3 profile domain-containing protein;putative metabotropic glutamate receptor mgl-1

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cysteine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cysteine biosynthetic process from serine IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cysteine biosynthetic process from serine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cysteine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in striated muscle dense body HDA PubMed 

General protein information

Preferred Names
Cysteine synthase 1
NP_001369978.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9952579..9954533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383632.2NP_001369978.1  Cysteine synthase 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93244
    Conserved Domains (1) summary
    cd01561
    Location:16306
    CBS_like; This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of ...