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DRD1 dopamine receptor D1 [ Homo sapiens (human) ]

Gene ID: 1812, updated on 18-Sep-2024

Summary

Official Symbol
DRD1provided by HGNC
Official Full Name
dopamine receptor D1provided by HGNC
Primary source
HGNC:HGNC:3020
See related
Ensembl:ENSG00000184845 MIM:126449; AllianceGenome:HGNC:3020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D1R; DADR; DRD1A
Summary
This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 3.4), placenta (RPKM 0.8) and 9 other tissues See more
Orthologs
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Genomic context

See DRD1 in Genome Data Viewer
Location:
5q35.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (175440036..175444182, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (175983814..175987960, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (174867039..174871185, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986484 Neighboring gene Sharpr-MPRA regulatory region 3886 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:174550039-174551238 Neighboring gene Sharpr-MPRA regulatory region 8865 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:174697681-174698880 Neighboring gene ARF like GTPase 2 binding protein pseudogene 6 Neighboring gene MPRA-validated peak5585 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr5:174756399-174756570 Neighboring gene NANOG hESC enhancer GRCh37_chr5:174789537-174790038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:174824457-174825029 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:174861879-174862482 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:174863593-174864097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16643 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16644 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr5:174905945-174906540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:174911541-174912114 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:174943953-174945152 Neighboring gene sideroflexin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat and methamphetamine inhibit the normal conjunction of signaling between D1 and NMDA receptors, resulting in neural dysfunction and death PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in D-glucose import IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adult walking behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in astrocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
involved_in behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to catecholamine stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cerebral cortex GABAergic interneuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in conditioned taste aversion IEA
Inferred from Electronic Annotation
more info
 
involved_in dentate gyrus development IEA
Inferred from Electronic Annotation
more info
 
involved_in dopamine metabolic process IC
Inferred by Curator
more info
PubMed 
involved_in dopamine transport IEA
Inferred from Electronic Annotation
more info
 
involved_in grooming behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in habituation IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term synaptic depression IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in maternal behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in mating behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
involved_in modification of postsynaptic structure IEA
Inferred from Electronic Annotation
more info
 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in operant conditioning IEA
Inferred from Electronic Annotation
more info
 
involved_in peristalsis IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in prepulse inhibition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in presynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dopamine uptake involved in synaptic transmission IC
Inferred by Curator
more info
PubMed 
involved_in response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sensitization IEA
Inferred from Electronic Annotation
more info
 
involved_in striatum development IEA
Inferred from Electronic Annotation
more info
 
involved_in synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
involved_in temperature homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in transmission of nerve impulse ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
 
involved_in visual learning ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of G protein-coupled receptor complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
D(1A) dopamine receptor
Names
dopamine D1 receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011802.1 RefSeqGene

    Range
    4979..9125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000794.5NP_000785.1  D(1A) dopamine receptor

    See identical proteins and their annotated locations for NP_000785.1

    Status: REVIEWED

    Source sequence(s)
    AC091393
    Consensus CDS
    CCDS4393.1
    UniProtKB/Swiss-Prot
    B2RA44, P21728, Q4QRJ0
    UniProtKB/TrEMBL
    Q6FH34
    Related
    ENSP00000377353.1, ENST00000393752.3
    Conserved Domains (1) summary
    cd15320
    Location:23341
    7tmA_D1A_dopamine_R; D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    175440036..175444182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    175983814..175987960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)