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gpx-5 Glutathione peroxidase [ Caenorhabditis elegans ]

Gene ID: 181178, updated on 2-Nov-2024

Summary

Official Symbol
gpx-5
Official Full Name
Glutathione peroxidase
Primary source
WormBase:WBGene00007516
Locus tag
CELE_C11E4.1
See related
AllianceGenome:WB:WBGene00007516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutathione peroxidase activity. Involved in response to reactive oxygen species. Predicted to be located in extracellular space. Is expressed in head; hypodermis; intestine; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cardiovascular system disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including GPX3 (glutathione peroxidase 3) and GPX5 (glutathione peroxidase 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See gpx-5 in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Sequence:
Chromosome: X; NC_003284.9 (9584668..9586344)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Glutathione peroxidase 3 Neighboring gene ncRNA Neighboring gene DEgenerin Like

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in response to chemical IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
Glutathione peroxidase
NP_509615.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9584668..9586344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077214.6NP_509615.3  Glutathione peroxidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509615.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93204
    Conserved Domains (1) summary
    cd00340
    Location:39203
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...