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vav-1 Protein vav-1 [ Caenorhabditis elegans ]

Gene ID: 181153, updated on 6-Sep-2019

Summary

Gene symbol
vav-1
Gene description
Protein vav-1
Primary source
WormBase:WBGene00006887
Locus tag
CELE_C35B8.2
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See vav-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Sequence:
Chromosome: X; NC_003284.9 (9216867..9232075, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Drosophila CRumBs homolog Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene COLlagen Neighboring gene ncRNA Neighboring gene Ligand-gated ion channel 4

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of vulval development IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
Protein vav-1
NP_001041222.1
  • Confirmed by transcript evidence
NP_001359918.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9216867..9232075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373412.1NP_001359918.1  Protein vav-1 [Caenorhabditis elegans]

    Status: REVIEWED

  2. NM_001373413.1NP_001360680.1  Protein vav-1 [Caenorhabditis elegans]

    Status: REVIEWED

  3. NM_001047757.3NP_001041222.1  Protein vav-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041222.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q45FX5
    Conserved Domains (7) summary
    cd09940
    Location:793893
    SH2_Vav_family; Src homology 2 (SH2) domain found in the Vav family
    smart00326
    Location:895955
    SH3; Src homology 3 domains
    cd00014
    Location:6117
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00029
    Location:584625
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:209403
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    pfam00169
    Location:447561
    PH; PH domain
    cl17171
    Location:421570
    PH-like; Pleckstrin homology-like domain
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