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Nnmt nicotinamide N-methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 18113, updated on 14-Mar-2023

Summary

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Official Symbol
Nnmtprovided by MGI
Official Full Name
nicotinamide N-methyltransferaseprovided by MGI
Primary source
MGI:MGI:1099443
See related
Ensembl:ENSMUSG00000032271 AllianceGenome:MGI:1099443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables nicotinamide N-methyltransferase activity. Involved in nicotinamide metabolic process; regulation of cellular biosynthetic process; and regulation of protein modification process. Acts upstream of or within methylation. Located in cytosol. Orthologous to human NNMT (nicotinamide N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 9.1), subcutaneous fat pad adult (RPKM 7.8) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Nnmt in Genome Data Viewer
Location:
9 A5.3; 9 26.45 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (48449300..48518955, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (48538002..48607655, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5617 Neighboring gene RNA binding motif protein 7 Neighboring gene predicted gene, 53521 Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene predicted gene, 32280

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase. Mizuno R, et al. Nat Commun, 2022 Jun 15. PMID 35705545, Free PMC Article
  2. Effect of nicotinamide N-methyltransferase on lipid accumulation in 3T3-L1 adipocytes. Xu W, et al. Bioengineered, 2022 May. PMID 35603729, Free PMC Article
  3. The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease. Takahashi R, et al. Sci Rep, 2022 Apr 16. PMID 35430611, Free PMC Article
  4. NNMT is induced dynamically during beige adipogenesis in adipose tissues depot-specific manner. Jia R, et al. J Physiol Biochem, 2022 Feb. PMID 34699038
  5. ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development. Song Q, et al. J Hepatol, 2020 Oct. PMID 32389809, Free PMC Article

See all (41) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.
    Title: Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.
  2. Effect of nicotinamide N-methyltransferase on lipid accumulation in 3T3-L1 adipocytes.
    Title: Effect of nicotinamide N-methyltransferase on lipid accumulation in 3T3-L1 adipocytes.
  3. NNMT is induced dynamically during beige adipogenesis in adipose tissues depot-specific manner.
    Title: NNMT is induced dynamically during beige adipogenesis in adipose tissues depot-specific manner.
  4. Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-beta1/Smad3 pathway.
    Title: Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-β1/Smad3 pathway.
  5. ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development.
    Title: ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development.
  6. Glucose availability regulates Nnmt expression in adipocytes.
    Title: Glucose availability regulates nicotinamide N-methyltransferase expression in adipocytes.
  7. These data indicate that NNMT links the NAD(+) and methionine metabolic pathways and promotes liver steatosis and fibrosis.
    Title: NNMT activation can contribute to the development of fatty liver disease by modulating the NAD (+) metabolism.
  8. by co-opting the enzymes of the methionine cycle, Nnmt aids the recycling of homocysteine to S-adenosylmethionine for another round of methylation.
    Title: Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism.
  9. Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide have been presented.
    Title: Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.
  10. NNMT is a novel regulator of histone methylation, polyamine flux and NAD(+)-dependent SIRT1 signalling, and is a unique and attractive target for treating obesity and type 2 diabetes
    Title: Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nicotinamide N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables nicotinamide N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinamide N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nicotinamide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nicotinamide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein deacetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nicotinamide N-methyltransferase
NP_001297991.1
NP_035054.1
XP_006510140.1
XP_011240719.1
XP_036010576.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311062.2 → NP_001297991.1  nicotinamide N-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113548
    Consensus CDS
    CCDS80991.1
    UniProtKB/TrEMBL
    A0A8C6H1W3, D3YX59
    Related
    ENSMUSP00000112381.2, ENSMUST00000119426.2
    Conserved Domains (1) summary
    cl17173
    Location:2 → 137
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001409262.1 → NP_001396191.1  nicotinamide N-methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113548
    UniProtKB/Swiss-Prot
    O55239
    UniProtKB/TrEMBL
    A0A8C6H1V2

  3. NM_001409263.1 → NP_001396192.1  nicotinamide N-methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113548
    UniProtKB/Swiss-Prot
    O55239
    UniProtKB/TrEMBL
    A0A8C6H1V2

  4. NM_001409264.1 → NP_001396193.1  nicotinamide N-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113548
    UniProtKB/TrEMBL
    A0A8C6H1W3, D3YX59

  5. NM_001409265.1 → NP_001396194.1  nicotinamide N-methyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113548, AC160992

  6. NM_001409266.1 → NP_001396195.1  nicotinamide N-methyltransferase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113548
    UniProtKB/TrEMBL
    Q9D9X3

  7. NM_001409267.1 → NP_001396196.1  nicotinamide N-methyltransferase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC113548

  8. NM_010924.4 → NP_035054.1  nicotinamide N-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_035054.1

    Status: VALIDATED

    Source sequence(s)
    AC113548
    Consensus CDS
    CCDS23157.1
    UniProtKB/Swiss-Prot
    O55239
    UniProtKB/TrEMBL
    A0A8C6H1V2, Q9D9X3
    Related
    ENSMUSP00000034808.6, ENSMUST00000034808.12
    Conserved Domains (1) summary
    pfam01234
    Location:2 → 259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    48449300..48518955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510077.5 → XP_006510140.1  nicotinamide N-methyltransferase isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:2 → 121
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_011242417.3 → XP_011240719.1  nicotinamide N-methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    O55239
    Conserved Domains (1) summary
    pfam01234
    Location:2 → 259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

  3. XM_036154683.1 → XP_036010576.1  nicotinamide N-methyltransferase isoform X1

    Conserved Domains (1) summary
    pfam01234
    Location:2 → 259
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55239.1 GenPept UniProtKB/Swiss-Prot:O55239

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