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Nnat neuronatin [ Mus musculus (house mouse) ]

Gene ID: 18111, updated on 24-Jan-2023

Summary

Official Symbol
Nnatprovided by MGI
Official Full Name
neuronatinprovided by MGI
Primary source
MGI:MGI:104716
See related
Ensembl:ENSMUSG00000067786 AllianceGenome:MGI:104716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Peg5; 5730414I02Rik
Summary
Acts upstream of or within positive regulation of insulin secretion and response to glucose. Located in cytoplasm. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human NNAT (neuronatin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 921.6), CNS E14 (RPKM 733.0) and 7 other tissues See more
Orthologs
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Genomic context

See Nnat in Genome Data Viewer
Location:
2 78.4 cM; 2 H1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157401936..157404445)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157560078..157562525)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1673 Neighboring gene predicted gene 14279 Neighboring gene bladder cancer associated protein Neighboring gene pluripotency associated transcript 27 Neighboring gene predicted gene, 34293

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291128.1NP_001278057.1  neuronatin isoform c

    See identical proteins and their annotated locations for NP_001278057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AK160626, AL672259, BQ030646, BU705167, DN176829
    Consensus CDS
    CCDS71174.1
    UniProtKB/Swiss-Prot
    Q61979
    UniProtKB/TrEMBL
    G3X9K1
    Related
    ENSMUSP00000085836.6, ENSMUST00000088484.6
  2. NM_001291129.1NP_001278058.1  neuronatin isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon but contains a different in-frame exon in the central coding region, compared to variant 3. The encoded isoform (d) is shorter than isoform c.
    Source sequence(s)
    AK160626, AL672259, BQ030646, BU705167, DV062509
    Consensus CDS
    CCDS71175.1
    UniProtKB/Swiss-Prot
    Q61979
    UniProtKB/TrEMBL
    G3UWR7
    Related
    ENSMUSP00000133397.2, ENSMUST00000173595.2
  3. NM_001291130.1NP_001278059.1  neuronatin isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon but contains a different exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform c.
    Source sequence(s)
    AK160626, AL672259, BQ030646, BU705167
    Consensus CDS
    CCDS79857.1
    UniProtKB/Swiss-Prot
    Q61979
    UniProtKB/TrEMBL
    G3UWR4
    Related
    ENSMUSP00000133394.2, ENSMUST00000173839.2
  4. NM_010923.3NP_035053.1  neuronatin isoform alpha

    See identical proteins and their annotated locations for NP_035053.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon but contains a different exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (alpha, also known as Neuronatin-3) has a distinct C-terminus and is shorter than isoform c.
    Source sequence(s)
    AK160626, AL672259, BQ030646, BU705167
    Consensus CDS
    CCDS38306.1
    UniProtKB/Swiss-Prot
    Q61979, Q61981
    UniProtKB/TrEMBL
    A0A6P5NU35
    Related
    ENSMUSP00000105152.2, ENSMUST00000109526.2
  5. NM_180960.3NP_851291.1  neuronatin isoform beta

    See identical proteins and their annotated locations for NP_851291.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (beta, also known as Neuronatin-2) has a distinct C-terminus and is shorter than isoform c.
    Source sequence(s)
    AK160626, AL672259, AU079843, BQ030646, BU705167
    Consensus CDS
    CCDS38307.1
    UniProtKB/Swiss-Prot
    Q61979
    UniProtKB/TrEMBL
    A0A6P7QW47, Q548P9
    Related
    ENSMUSP00000129821.2, ENSMUST00000153739.9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    157401936..157404445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159369.1XP_036015262.1  neuronatin isoform X1