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Mycn v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived [ Mus musculus (house mouse) ]

Gene ID: 18109, updated on 26-Sep-2022

Summary

Official Symbol
Mycnprovided by MGI
Official Full Name
v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derivedprovided by MGI
Primary source
MGI:MGI:97357
See related
Ensembl:ENSMUSG00000037169 AllianceGenome:MGI:97357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nmyc; N-myc; Nmyc1; Nmyc-1; c-nmyc; bHLHe37
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and kinase binding activity. Involved in negative regulation of reactive oxygen species metabolic process and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic digit morphogenesis; negative regulation of astrocyte differentiation; and skeletal system morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 25.9), CNS E14 (RPKM 22.7) and 14 other tissues See more
Orthologs
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Genomic context

See Mycn in Genome Data Viewer
Location:
12 A1.1; 12 6.14 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (12986094..12991837, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (12936093..12941836, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35155 Neighboring gene ribosomal protein L36, pseudogene 3 Neighboring gene predicted gene, 40271 Neighboring gene ES cell cis-regulatory motif 2b Neighboring gene 40S ribosomal protein S16 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (15)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of astrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of astrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of inner ear auditory receptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
N-myc proto-oncogene protein
Names
neuroblastoma myc-related oncogene 1
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008709.3NP_032735.3  N-myc proto-oncogene protein

    See identical proteins and their annotated locations for NP_032735.3

    Status: VALIDATED

    Source sequence(s)
    AK146696, BY644089
    Consensus CDS
    CCDS25818.1
    UniProtKB/Swiss-Prot
    P03966, Q61978
    UniProtKB/TrEMBL
    Q3UII1
    Related
    ENSMUSP00000045993.8, ENSMUST00000043396.15
    Conserved Domains (2) summary
    cd00083
    Location:377436
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:10370
    Myc_N; Myc amino-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    12986094..12991837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)