Format

Send to:

Choose Destination

Mycn v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived [ Mus musculus (house mouse) ]

Gene ID: 18109, updated on 6-Jan-2019

Summary

Official Symbol
Mycnprovided by MGI
Official Full Name
v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derivedprovided by MGI
Primary source
MGI:MGI:97357
See related
Ensembl:ENSMUSG00000037169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nmyc; N-myc; Nmyc1; Nmyc-1; c-nmyc; bHLHe37
Expression
Biased expression in CNS E11.5 (RPKM 25.9), CNS E14 (RPKM 22.7) and 14 other tissues See more
Orthologs

Genomic context

See Mycn in Genome Data Viewer
Location:
12 A1.1; 12 6.14 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (12936093..12941836, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (12942899..12948642, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35155 Neighboring gene ribosomal protein L36, pseudogene 3 Neighboring gene predicted gene, 40271 Neighboring gene predicted gene, 35208 Neighboring gene predicted gene, 35350

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of astrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of inner ear auditory receptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
N-myc proto-oncogene protein
Names
neuroblastoma myc-related oncogene 1
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008709.3NP_032735.3  N-myc proto-oncogene protein

    See identical proteins and their annotated locations for NP_032735.3

    Status: VALIDATED

    Source sequence(s)
    AK146696, BY644089
    Consensus CDS
    CCDS25818.1
    UniProtKB/Swiss-Prot
    P03966
    UniProtKB/TrEMBL
    Q3UII1
    Related
    ENSMUSP00000045993.7, ENSMUST00000043396.14
    Conserved Domains (2) summary
    cd00083
    Location:377436
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:10370
    Myc_N; Myc amino-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    12936093..12941836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center