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sdpn-1 SH3 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181058, updated on 9-Dec-2024

Summary

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Official Symbol
sdpn-1
Official Full Name
SH3 domain-containing protein
Primary source
WormBase:WBGene00018467
Locus tag
CELE_F45E1.7
See related
AllianceGenome:WB:WBGene00018467
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phospholipid binding activity. Involved in endocytic recycling. Located in early endosome and recycling endosome membrane. Is expressed in intestine and pharynx. Used to study Huntington's disease and neurodegenerative disease. Orthologous to human PACSIN1 (protein kinase C and casein kinase substrate in neurons 1); PACSIN2 (protein kinase C and casein kinase substrate in neurons 2); and PACSIN3 (protein kinase C and casein kinase substrate in neurons 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sdpn-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (7988931..7998229, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Rhodanese domain-containing protein Neighboring gene Histone H3.3 type 1 Neighboring gene Phosphoglycolate phosphatase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene KfrA_N domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy. Oe Y, et al. PLoS Genet, 2022 Jun. PMID 35771772, Free PMC Article
  2. Syndapin/SDPN-1 is required for endocytic recycling and endosomal actin association in the C. elegans intestine. Gleason AM, et al. Mol Biol Cell, 2016 Sep 14. PMID 27630264, Free PMC Article
  3. Age-associated decline in RAB-10 efficacy impairs intestinal barrier integrity. Zhang J, et al. Nat Aging, 2023 Sep. PMID 37640905
  4. A novel requirement for C. elegans Alix/ALX-1 in RME-1-mediated membrane transport. Shi A, et al. Curr Biol, 2007 Nov 20. PMID 17997305, Free PMC Article
  5. Interactions between Rab and Arf GTPases regulate endosomal phosphatidylinositol-4,5-bisphosphate during endocytic recycling. Shi A, et al. Small GTPases, 2013 Apr-Jun. PMID 23392104, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SH3 domain-containing protein
NP_001367621.1
  • Confirmed by transcript evidence
NP_001367622.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7988931..7998229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001381035.1 → NP_001367621.1  SH3 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q09989
    Conserved Domains (2) summary
    cd07655
    Location:10 → 267
    F-BAR_PACSIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
    cl17036
    Location:431 → 483
    SH3; Src Homology 3 domain superfamily

  2. NM_001381034.1 → NP_001367622.1  SH3 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AHQ8
    Conserved Domains (2) summary
    cd07655
    Location:16 → 273
    F-BAR_PACSIN; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons (PACSIN) proteins
    cl17036
    Location:437 → 489
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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