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sek-1 Dual specificity mitogen-activated protein kinase kinase sek-1 [ Caenorhabditis elegans ]

Gene ID: 181043, updated on 22-Jan-2020

Summary

Gene symbol
sek-1
Gene description
Dual specificity mitogen-activated protein kinase kinase sek-1
Primary source
WormBase:WBGene00004758
Locus tag
CELE_R03G5.2
Gene type
protein coding
RNA name
Dual specificity mitogen-activated protein kinase kinase sek-1
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See sek-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (7816734..7821045)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Glutathione peroxidase Neighboring gene pseudo Neighboring gene hypothetical protein Neighboring gene Elongation factor 1-alpha Neighboring gene ncRNA

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
activation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of left/right asymmetry in nervous system IGI
Inferred from Genetic Interaction
more info
PubMed 
determination of left/right asymmetry in nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oviposition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of defense response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of oviposition IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to nematicide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to superoxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
turning behavior involved in mating IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Dual specificity mitogen-activated protein kinase kinase sek-1
NP_509322.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7816734..7821045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076921.5NP_509322.2  Dual specificity mitogen-activated protein kinase kinase sek-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509322.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EDF7
    Conserved Domains (2) summary
    cd06617
    Location:48328
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    smart00220
    Location:52311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
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