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deg-1 Degenerin deg-1 [ Caenorhabditis elegans ]

Gene ID: 181035, updated on 2-Dec-2025
Official Symbol
deg-1
Official Full Name
Degenerin deg-1
Primary source
WormBase:WBGene00000950
Locus tag
CELE_C47C12.6
See related
AllianceGenome:WB:WBGene00000950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ligand-gated sodium channel activity. Involved in response to acidic pH and response to amino acid. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in AVG; IL1 neuron; anal depressor muscle; body wall musculature; and command interneuron. Used to study hypokalemic periodic paralysis and neurodegenerative disease. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
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See deg-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
22
Sequence:
Chromosome: X; NC_003284.9 (7753070..7774817)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene RGS domain-containing protein Neighboring gene Zinc finger transcription factor ref-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene tRNA-Asn Neighboring gene ncRNA Neighboring gene tRNA-Asn Neighboring gene tRNA-Asn Neighboring gene Tubulin beta-1 chain Neighboring gene uncharacterized protein Neighboring gene Apple domain-containing protein

Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. DEG/ENaCs lead by a nose: mechanotransduction in a polymodal sensory neuron. Nelson AM, et al. Neuron, 2011 Sep 8. PMID 21903069
  2. DEG/ENaC but not TRP channels are the major mechanoelectrical transduction channels in a C. elegans nociceptor. Geffeney SL, et al. Neuron, 2011 Sep 8. PMID 21903078, Free PMC Article
  3. Neuropathology of degenerative cell death in Caenorhabditis elegans. Hall DH, et al. J Neurosci, 1997 Feb 1. PMID 8994058, Free PMC Article
  4. A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans. Wang Y, et al. EMBO J, 2008 Sep 17. PMID 18701922, Free PMC Article
  5. The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration. Driscoll M, et al. Nature, 1991 Feb 14. PMID 1672038

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans.
    Title: The mechanoreceptor DEG-1 regulates cold tolerance in Caenorhabditis elegans.
  2. OSM-9 and an amiloride-sensitive channel, DEG-1, but not PKD-2, are involved in mechanosensation in C. elegans male ray neurons.
    Title: OSM-9 and an amiloride-sensitive channel, but not PKD-2, are involved in mechanosensation in C. elegans male ray neurons.
  3. These data suggest that DEG/ENaC but not TRP channels are the major critical role in later steps of sensory perception: encoding and transmission of sensory information, but not in detection.
    Title: DEG/ENaC but not TRP channels are the major mechanoelectrical transduction channels in a C. elegans nociceptor.
  4. the glial DEG/ENaC channel ACD-1 functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans
    Title: A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans.
  5. perception of mechanical stress controls FoxO signaling pathways and inactivation of DEG/ENaC may decouple mechanical loading and physiological responses.
    Title: Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to acidic pH IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to amino acid IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to amino acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Degenerin deg-1
NP_001360706.1
  • Partially confirmed by transcript evidence
NP_001360707.1
  • Partially confirmed by transcript evidence
NP_001360708.1
  • Partially confirmed by transcript evidence
NP_001360709.1
  • Confirmed by transcript evidence
NP_001360710.1
  • Confirmed by transcript evidence
NP_001360711.1
  • Partially confirmed by transcript evidence
NP_509311.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7753070..7774817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373369.2 → NP_001360711.1  Degenerin deg-1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ILZ4
    Conserved Domains (1) summary
    TIGR00867
    Location:39 → 710
    deg-1; degenerin

  2. NM_076910.5 → NP_509311.1  Degenerin deg-1

    See identical proteins and their annotated locations for NP_509311.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P24585
    Conserved Domains (2) summary
    TIGR00867
    Location:58 → 730
    deg-1; degenerin
    pfam00858
    Location:431 → 730
    ASC; Amiloride-sensitive sodium channel

  3. NM_001373370.2 → NP_001360706.1  Degenerin deg-1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IN98
    Conserved Domains (1) summary
    TIGR00867
    Location:58 → 796
    deg-1; degenerin

  4. NM_001373371.2 → NP_001360707.1  Degenerin deg-1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V6M3V2
    Conserved Domains (1) summary
    TIGR00867
    Location:58 → 740
    deg-1; degenerin

  5. NM_001373372.2 → NP_001360708.1  Degenerin deg-1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IKC5
    Conserved Domains (1) summary
    TIGR00867
    Location:58 → 722
    deg-1; degenerin

  6. NM_001373373.2 → NP_001360709.1  Degenerin deg-1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IJ47
    Conserved Domains (1) summary
    TIGR00867
    Location:58 → 786
    deg-1; degenerin

  7. NM_001373374.2 → NP_001360710.1  Degenerin deg-1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ILJ5
    Conserved Domains (1) summary
    TIGR00867
    Location:58 → 712
    deg-1; degenerin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24585.2

Gene LinkOut

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