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Nme2 NME/NM23 nucleoside diphosphate kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 18103, updated on 26-Sep-2022

Summary

Official Symbol
Nme2provided by MGI
Official Full Name
NME/NM23 nucleoside diphosphate kinase 2provided by MGI
Primary source
MGI:MGI:97356
See related
Ensembl:ENSMUSG00000020857 AllianceGenome:MGI:97356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NM23B; NM23-H2; nm23-M2
Summary
Predicted to enable several functions, including G-quadruplex DNA binding activity; anion binding activity; and kinase activity. Predicted to be involved in several processes, including negative regulation of myeloid leukocyte differentiation; nucleotide metabolic process; and protein autophosphorylation. Predicted to act upstream of or within nucleotide metabolic process and phosphorylation. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in teratoma. Orthologous to several human genes including NME1-NME2 (NME1-NME2 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 169.6), liver E18 (RPKM 106.9) and 28 other tissues See more
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Genomic context

See Nme2 in Genome Data Viewer
Location:
11; 11 D
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (93840640..93847082, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (93949814..93956256, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene UTP18 small subunit processome component Neighboring gene ES cell cis-regulatory motifs 1a, 3b and 9b Neighboring gene mbt domain containing 1 Neighboring gene predicted gene, 35198 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene sperm associated antigen 9 Neighboring gene ribosomal protein L27 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107562, MGC107563

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables G-quadruplex DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables intermediate filament binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with intermediate filament ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in myelin sheath HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nucleoside diphosphate kinase B
Names
NDK B
NDP kinase B
P18
expressed in non-metastatic cells 2 protein
histidine protein kinase NDKB
non-metastatic cells 2, protein (NM23B) expressed in
nucleoside-diphosphate kinase 2
NP_001070997.1
NP_032731.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077529.2NP_001070997.1  nucleoside diphosphate kinase B

    See identical proteins and their annotated locations for NP_001070997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK216511, AV458476, BC086892
    Consensus CDS
    CCDS25246.1
    UniProtKB/Swiss-Prot
    Q01768
    UniProtKB/TrEMBL
    A0A6P5QS96, A0A8C6GLC7, Q5NC82
    Related
    ENSMUSP00000103476.2, ENSMUST00000072566.5
    Conserved Domains (1) summary
    PTZ00093
    Location:3151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
  2. NM_008705.5NP_032731.1  nucleoside diphosphate kinase B

    See identical proteins and their annotated locations for NP_032731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    BC066995, BC086893
    Consensus CDS
    CCDS25246.1
    UniProtKB/Swiss-Prot
    Q01768
    UniProtKB/TrEMBL
    A0A6P5QS96, A0A8C6GLC7, Q5NC82
    Related
    ENSMUSP00000021217.5, ENSMUST00000021217.11
    Conserved Domains (1) summary
    PTZ00093
    Location:3151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    93840640..93847082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)