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Nme2 NME/NM23 nucleoside diphosphate kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 18103, updated on 2-Oct-2018

Summary

Official Symbol
Nme2provided by MGI
Official Full Name
NME/NM23 nucleoside diphosphate kinase 2provided by MGI
Primary source
MGI:MGI:97356
See related
Ensembl:ENSMUSG00000020857 Vega:OTTMUSG00000001491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NM23B; NM23-H2; nm23-M2
Expression
Ubiquitous expression in placenta adult (RPKM 169.6), liver E18 (RPKM 106.9) and 28 other tissues See more
Orthologs

Genomic context

See Nme2 in Genome Data Viewer
Location:
11; 11 D
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (93949814..93956256, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (93811129..93817321, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene UTP18 small subunit processome component Neighboring gene mbt domain containing 1 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene predicted gene, 35198

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107562, MGC107563

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
G-quadruplex DNA binding ISO
Inferred from Sequence Orthology
more info
 
GDP binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
intermediate filament binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
CTP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
GTP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
UTP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myeloid leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
nucleoside diphosphate phosphorylation ISO
Inferred from Sequence Orthology
more info
 
nucleoside triphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of epidermis development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with intermediate filament ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nucleoside diphosphate kinase B
Names
NDK B
NDP kinase B
P18
expressed in non-metastatic cells 2 protein
histidine protein kinase NDKB
non-metastatic cells 2, protein (NM23B) expressed in
nucleoside-diphosphate kinase 2
NP_001070997.1
NP_032731.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077529.2NP_001070997.1  nucleoside diphosphate kinase B

    See identical proteins and their annotated locations for NP_001070997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK216511, AV458476, BC086892
    Consensus CDS
    CCDS25246.1
    UniProtKB/Swiss-Prot
    Q01768
    UniProtKB/TrEMBL
    Q5NC82
    Related
    ENSMUSP00000103476.1, OTTMUSP00000001444, ENSMUST00000072566.4, OTTMUST00000002955
    Conserved Domains (1) summary
    PTZ00093
    Location:3151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional
  2. NM_008705.5NP_032731.1  nucleoside diphosphate kinase B

    See identical proteins and their annotated locations for NP_032731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    BC066995, BC086893
    Consensus CDS
    CCDS25246.1
    UniProtKB/Swiss-Prot
    Q01768
    UniProtKB/TrEMBL
    Q5NC82
    Related
    ENSMUSP00000021217.4, OTTMUSP00000001443, ENSMUST00000021217.10, OTTMUST00000002954
    Conserved Domains (1) summary
    PTZ00093
    Location:3151
    PTZ00093; nucleoside diphosphate kinase, cytosolic; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    93949814..93956256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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