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AGRP agouti related neuropeptide [ Homo sapiens (human) ]

Gene ID: 181, updated on 4-May-2020

Summary

Official Symbol
AGRPprovided by HGNC
Official Full Name
agouti related neuropeptideprovided by HGNC
Primary source
HGNC:HGNC:330
See related
Ensembl:ENSG00000159723 MIM:602311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ART; AGRT; ASIP2
Summary
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
Expression
Biased expression in adrenal (RPKM 1.6), lung (RPKM 0.8) and 5 other tissues See more
Orthologs

Genomic context

See AGRP in Genome Data Viewer
Location:
16q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67482571..67483547, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67516474..67517716, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene ATPase H+ transporting V0 subunit d1 Neighboring gene uncharacterized LOC101927837 Neighboring gene uncharacterized LOC100505942 Neighboring gene RHO family interacting cell polarization regulator 1 Neighboring gene uncharacterized LOC107984813

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC118963

Gene Ontology Provided by GOA

Function Evidence Code Pubs
melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
type 1 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
adult feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adult feeding behavior IEA
Inferred from Electronic Annotation
more info
 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
feeding behavior TAS
Traceable Author Statement
more info
PubMed 
hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
long-day photoperiodism IEA
Inferred from Electronic Annotation
more info
 
maternal process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of feeding behavior IDA
Inferred from Direct Assay
more info
PubMed 
regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi lumen IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
agouti-related protein
Names
agouti related protein homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011501.1 RefSeqGene

    Range
    5267..6243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001138.2NP_001129.1  agouti-related protein precursor

    See identical proteins and their annotated locations for NP_001129.1

    Status: REVIEWED

    Source sequence(s)
    AC009061
    Consensus CDS
    CCDS10839.1
    UniProtKB/Swiss-Prot
    O00253
    UniProtKB/TrEMBL
    C6SUN5
    Related
    ENSP00000290953.2, ENST00000290953.2
    Conserved Domains (1) summary
    smart00792
    Location:1122
    Agouti; Agouti protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67482571..67483547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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