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C07D8.6 NADP-dependent oxidoreductase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180997, updated on 2-Dec-2025
Official Symbol
C07D8.6
Official Full Name
NADP-dependent oxidoreductase domain-containing protein
Primary source
WormBase:WBGene00015565
Locus tag
CELE_C07D8.6
See related
AllianceGenome:WB:WBGene00015565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aldose reductase (NADPH) activity. Predicted to be active in cytosol. Is expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal 8; alcohol dependence; congenital bile acid synthesis defect 2; leukemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B); AKR1B10 (aldo-keto reductase family 1 member B10); and AKR1B15 (aldo-keto reductase family 1 member B15). [provided by Alliance of Genome Resources, Jul 2025]
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See C07D8.6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (7341509..7342780)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene TransThyretin-Related family domain Neighboring gene Autophagy-related protein 11 C-terminal domain-containing protein Neighboring gene NADP-dependent oxidoreductase domain-containing protein Neighboring gene pseudo

Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease. Taylor RC, et al. J Biol Chem, 2007 May 18. PMID 17371877
  2. A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans. Binti S, et al. PLoS Genet, 2024 Aug. PMID 39173071, Free PMC Article
  3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  5. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
NADP-dependent oxidoreductase domain-containing protein
NP_509242.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7341509..7342780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076841.8 → NP_509242.1  NADP-dependent oxidoreductase domain-containing protein

    See identical proteins and their annotated locations for NP_509242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91020
    Conserved Domains (1) summary
    cd19154
    Location:5 → 301
    AKR_AKR1G1_CeAKR; Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins
Nucleotide Protein
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