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Nkx6-1 NK6 homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 18096, updated on 18-Jun-2024

Summary

Official Symbol
Nkx6-1provided by MGI
Official Full Name
NK6 homeobox 1provided by MGI
Primary source
MGI:MGI:1206039
See related
Ensembl:ENSMUSG00000035187 AllianceGenome:MGI:1206039
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NKX6A; Nkx6.1
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including neurogenesis; regulation of axon extension; and regulation of neuron migration. Located in nucleus. Is expressed in several structures, including central nervous system; future brain; and gut. Orthologous to human NKX6-1 (NK6 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 6.3), stomach adult (RPKM 2.0) and 3 other tissues See more
Orthologs
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Genomic context

See Nkx6-1 in Genome Data Viewer
Location:
5 E4- E5; 5 48.84 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (101807050..101812577, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (101659184..101664711, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29982 Neighboring gene predicted gene, 42132 Neighboring gene RIKEN cDNA 9430085M18 gene Neighboring gene STARR-seq mESC enhancer starr_13743 Neighboring gene predicted gene, 42134

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within central nervous system neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocrine pancreas development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neurogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pancreatic A cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within type B pancreatic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type B pancreatic cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein Nkx-6.1
Names
Drosophila NK transcription factor related, gene family 6, locus 1
NK6 transcription factor related, locus 1
homeobox protein NK-6 homolog A
homeodomain transcription factor Nkx6.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144955.2NP_659204.1  homeobox protein Nkx-6.1

    See identical proteins and their annotated locations for NP_659204.1

    Status: PROVISIONAL

    Source sequence(s)
    AC105976
    Consensus CDS
    CCDS19471.1
    UniProtKB/Swiss-Prot
    B2RQP4, Q99MA9, Q9ERQ7
    Related
    ENSMUSP00000042716.9, ENSMUST00000044125.11
    Conserved Domains (2) summary
    pfam00046
    Location:240293
    Homeobox; Homeobox domain
    pfam11861
    Location:291345
    DUF3381; Domain of unknown function (DUF3381)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    101807050..101812577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)