Format

Send to:

Choose Destination

Nkx3-1 NK3 homeobox 1 [ Mus musculus (house mouse) ]

Gene ID: 18095, updated on 15-Jan-2019

Summary

Official Symbol
Nkx3-1provided by MGI
Official Full Name
NK3 homeobox 1provided by MGI
Primary source
MGI:MGI:97352
See related
Ensembl:ENSMUSG00000022061
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bax; NKX3A; NKX3.1; Nkx-3.1; bagpipe
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See Nkx3-1 in Genome Data Viewer
Location:
14 D2; 14 36.02 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (69190692..69194658)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (69808749..69812715)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700092C10 gene Neighboring gene NK2 homeobox 6 Neighboring gene predicted gene, 31632 Neighboring gene predicted gene, 37762 Neighboring gene solute carrier family 25, member 37 Neighboring gene predicted gene, 31896

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Prostate cancer, organism-specific biosystem (from KEGG)
    Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • Prostate cancer, conserved biosystem (from KEGG)
    Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
MADS box domain binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase activator activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor activity ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
branching involved in prostate gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
dorsal aorta development IEP
Inferred from Expression Pattern
more info
PubMed 
epithelial cell proliferation involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IEP
Inferred from Expression Pattern
more info
PubMed 
internal genitalia morphogenesis TAS
Traceable Author Statement
more info
PubMed 
male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
metanephros development IEP
Inferred from Expression Pattern
more info
PubMed 
mitotic cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
pharyngeal system development IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of androgen secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
prostate gland development IEP
Inferred from Expression Pattern
more info
PubMed 
prostate gland development TAS
Traceable Author Statement
more info
PubMed 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to testosterone IMP
Inferred from Mutant Phenotype
more info
PubMed 
salivary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
somitogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
urogenital system development IEP
Inferred from Expression Pattern
more info
PubMed 
urogenital system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
site of DNA damage ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
homeobox protein Nkx-3.1
Names
Drosophila NK-3 transcription factor, locus 1
NK-3 transcription factor, locus 1
homeobox protein NK-3 homolog A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010921.3NP_035051.1  homeobox protein Nkx-3.1

    See identical proteins and their annotated locations for NP_035051.1

    Status: PROVISIONAL

    Source sequence(s)
    CT025562
    Consensus CDS
    CCDS27237.1
    UniProtKB/Swiss-Prot
    P97436
    UniProtKB/TrEMBL
    Q3UVH8
    Related
    ENSMUSP00000022646.8, ENSMUST00000022646.8
    Conserved Domains (1) summary
    pfam00046
    Location:128181
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    69190692..69194658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center