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asp-3 Aspartic protease 3 [ Caenorhabditis elegans ]

Gene ID: 180947, updated on 2-Nov-2024

Summary

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Official Symbol
asp-3
Official Full Name
Aspartic protease 3
Primary source
WormBase:WBGene00000216
Locus tag
CELE_H22K11.1
See related
AllianceGenome:WB:WBGene00000216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aspartic-type endopeptidase activity. Involved in programmed necrotic cell death. Located in lysosome. Is expressed in intestine and uterus. Orthologous to human NAPSA (napsin A aspartic peptidase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See asp-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (6791064..6792709)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Glycoside hydrolase 35 catalytic domain-containing protein Neighboring gene CADG domain-containing protein;Dystroglycan-type cadherin-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteolytic mechanisms in necrotic cell death and neurodegeneration. Artal-Sanz M, et al. FEBS Lett, 2005 Jun 13. PMID 15943973
  2. A Disease Model of Muscle Necrosis Caused by Aeromonas dhakensis Infection in Caenorhabditis elegans. Chen PL, et al. Front Microbiol, 2016. PMID 28101079, Free PMC Article
  3. Paralysis of nematodes: shifts in the transcriptome of the nematode-trapping fungus Monacrosporium haptotylum during infection of Caenorhabditis elegans. Fekete C, et al. Environ Microbiol, 2008 Feb. PMID 18028414
  4. Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1. Tcherepanova I, et al. J Biol Chem, 2000 Aug 25. PMID 10854422
  5. First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6. Lochnit G, et al. Biol Chem, 2006 Oct-Nov. PMID 17081123

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in programmed necrotic cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aspartic protease 3
NP_509142.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6791064..6792709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076741.8 → NP_509142.2  Aspartic protease 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509142.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P55956, Q9TXI5
    Conserved Domains (2) summary
    pfam00026
    Location:68 → 393
    Asp; Eukaryotic aspartyl protease
    cl11403
    Location:59 → 393
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55956.3

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