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Nkx2-2 NK2 homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 18088, updated on 18-Apr-2024

Summary

Official Symbol
Nkx2-2provided by MGI
Official Full Name
NK2 homeobox 2provided by MGI
Primary source
MGI:MGI:97347
See related
Ensembl:ENSMUSG00000027434 AllianceGenome:MGI:97347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nkx2.2; tinman; Nkx-2.2
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including enteroendocrine cell differentiation; neurogenesis; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; neural ectoderm; and sensory organ. Orthologous to human NKX2-2 (NK2 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 1.9), CNS E11.5 (RPKM 1.6) and 10 other tissues See more
Orthologs
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Genomic context

Location:
2 G2; 2 72.63 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (146967909..147037270, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (147176485..147195434, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05957 Neighboring gene 5'-3' exoribonuclease 2 Neighboring gene predicted gene, 34889 Neighboring gene NK2 homeobox 4 Neighboring gene predicted gene, 57697 Neighboring gene predicted gene 14116 Neighboring gene RIKEN cDNA 6430503K07 gene Neighboring gene Nkx2-2 Hedgehog-responsive enhancer Neighboring gene STARR-seq mESC enhancer starr_05959 Neighboring gene NK2 homeobox 2, opposite strand Neighboring gene predicted gene, 39955 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuroendocrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pancreatic A cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pancreatic A cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pancreatic PP cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord oligodendrocyte cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within type B pancreatic cell development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of type B pancreatic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within type B pancreatic cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventral spinal cord interneuron fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
homeobox protein Nkx-2.2
Names
Drosophila NK2 transcription factor related, locus 2
NK2 transcription factor related, locus 2
glycoprotein GP330, renal
homeobox protein NK-2 homolog B
homeobox protein Nkx2-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077632.2NP_001071100.1  homeobox protein Nkx-2.2 isoform 2

    See identical proteins and their annotated locations for NP_001071100.1

    Status: VALIDATED

    Source sequence(s)
    AL928876, AL929317
    Consensus CDS
    CCDS38259.1
    UniProtKB/TrEMBL
    Q8BRS9
    Related
    ENSMUSP00000105596.4, ENSMUST00000109970.5
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain
  2. NM_001420453.1NP_001407382.1  homeobox protein Nkx-2.2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL928876, AL929317
  3. NM_010919.3NP_035049.1  homeobox protein Nkx-2.2 isoform 1

    See identical proteins and their annotated locations for NP_035049.1

    Status: VALIDATED

    Source sequence(s)
    AL929317
    Consensus CDS
    CCDS16834.1
    UniProtKB/Swiss-Prot
    P42586
    UniProtKB/TrEMBL
    Q3URZ4
    Related
    ENSMUSP00000069666.6, ENSMUST00000067075.7
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    146967909..147037270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159329.1XP_036015222.1  homeobox protein Nkx-2.2 isoform X2

    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain
  2. XM_036159345.1XP_036015238.1  homeobox protein Nkx-2.2 isoform X5

    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain
  3. XM_036159330.1XP_036015223.1  homeobox protein Nkx-2.2 isoform X3

    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain
  4. XM_036159341.1XP_036015234.1  homeobox protein Nkx-2.2 isoform X4

    UniProtKB/TrEMBL
    Q8BRS9
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain
  5. XM_036159331.1XP_036015224.1  homeobox protein Nkx-2.2 isoform X4

    UniProtKB/TrEMBL
    Q8BRS9
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain
  6. XM_036159335.1XP_036015228.1  homeobox protein Nkx-2.2 isoform X4

    UniProtKB/TrEMBL
    Q8BRS9
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain
  7. XM_036159347.1XP_036015240.1  homeobox protein Nkx-2.2 isoform X6

    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain
  8. XM_006498900.5XP_006498963.1  homeobox protein Nkx-2.2 isoform X1

    See identical proteins and their annotated locations for XP_006498963.1

    UniProtKB/Swiss-Prot
    P42586
    UniProtKB/TrEMBL
    Q3URZ4
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain
  9. XM_011239349.4XP_011237651.1  homeobox protein Nkx-2.2 isoform X1

    See identical proteins and their annotated locations for XP_011237651.1

    UniProtKB/Swiss-Prot
    P42586
    UniProtKB/TrEMBL
    Q3URZ4
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain
  10. XM_006498899.4XP_006498962.1  homeobox protein Nkx-2.2 isoform X1

    See identical proteins and their annotated locations for XP_006498962.1

    UniProtKB/Swiss-Prot
    P42586
    UniProtKB/TrEMBL
    Q3URZ4
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain
  11. XM_036159325.1XP_036015218.1  homeobox protein Nkx-2.2 isoform X1

    UniProtKB/Swiss-Prot
    P42586
    UniProtKB/TrEMBL
    Q3URZ4
    Conserved Domains (1) summary
    pfam00046
    Location:131185
    Homeobox; Homeobox domain

RNA

  1. XR_004938823.1 RNA Sequence