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Nkx2-2 NK2 homeobox 2 [ Mus musculus (house mouse) ]

Gene ID: 18088, updated on 3-Sep-2019

Summary

Official Symbol
Nkx2-2provided by MGI
Official Full Name
NK2 homeobox 2provided by MGI
Primary source
MGI:MGI:97347
See related
Ensembl:ENSMUSG00000027434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nkx2.2; tinman; Nkx-2.2
Expression
Biased expression in cerebellum adult (RPKM 1.9), CNS E11.5 (RPKM 1.6) and 10 other tissues See more
Orthologs

Genomic context

See Nkx2-2 in Genome Data Viewer
Location:
2 G2; 2 72.63 cM
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (147176485..147195434, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (147003282..147012138, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene predicted gene 14116 Neighboring gene RIKEN cDNA 6430503K07 gene Neighboring gene Nkx2-2 Hedgehog-responsive enhancer Neighboring gene NK2 homeobox 2, opposite strand Neighboring gene predicted gene, 39955 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
neuron fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
pancreatic A cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
pancreatic A cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
pancreatic PP cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
spinal cord oligodendrocyte cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
spinal cord oligodendrocyte cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
spinal cord oligodendrocyte cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
type B pancreatic cell development IDA
Inferred from Direct Assay
more info
PubMed 
type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
type B pancreatic cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventral spinal cord interneuron fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
homeobox protein Nkx-2.2
Names
Drosophila NK2 transcription factor related, locus 2
NK2 transcription factor related, locus 2
glycoprotein GP330, renal
homeobox protein NK-2 homolog B
homeobox protein Nkx2-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077632.1NP_001071100.1  homeobox protein Nkx-2.2 isoform 2

    See identical proteins and their annotated locations for NP_001071100.1

    Status: VALIDATED

    Source sequence(s)
    AK043561, AL929317, BB183898
    Consensus CDS
    CCDS38259.1
    UniProtKB/TrEMBL
    Q8BRS9
    Related
    ENSMUSP00000105596.3, ENSMUST00000109970.4
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain
  2. NM_010919.2NP_035049.1  homeobox protein Nkx-2.2 isoform 1

    See identical proteins and their annotated locations for NP_035049.1

    Status: VALIDATED

    Source sequence(s)
    AL929317
    Consensus CDS
    CCDS16834.1
    UniProtKB/Swiss-Prot
    P42586
    UniProtKB/TrEMBL
    Q3URZ4
    Related
    ENSMUSP00000069666.5, ENSMUST00000067075.6
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p6 C57BL/6J

    Range
    147176485..147195434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498900.4XP_006498963.1  homeobox protein Nkx-2.2 isoform X1

    See identical proteins and their annotated locations for XP_006498963.1

    UniProtKB/Swiss-Prot
    P42586
    UniProtKB/TrEMBL
    Q3URZ4
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain
  2. XM_011239349.3XP_011237651.1  homeobox protein Nkx-2.2 isoform X1

    See identical proteins and their annotated locations for XP_011237651.1

    UniProtKB/Swiss-Prot
    P42586
    UniProtKB/TrEMBL
    Q3URZ4
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain
  3. XM_030248255.1XP_030104115.1  homeobox protein Nkx-2.2 isoform X1

  4. XM_006498899.3XP_006498962.1  homeobox protein Nkx-2.2 isoform X1

    See identical proteins and their annotated locations for XP_006498962.1

    UniProtKB/Swiss-Prot
    P42586
    UniProtKB/TrEMBL
    Q3URZ4
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain
  5. XM_006498898.3XP_006498961.1  homeobox protein Nkx-2.2 isoform X1

    See identical proteins and their annotated locations for XP_006498961.1

    UniProtKB/Swiss-Prot
    P42586
    UniProtKB/TrEMBL
    Q3URZ4
    Conserved Domains (1) summary
    pfam00046
    Location:131184
    Homeobox; Homeobox domain
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